| Nogo-66受体在神经元生长锥中的表达 |
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| 引用本文： | 熊南翔,赵洪洋,张方成.Nogo-66受体在神经元生长锥中的表达[J].神经解剖学杂志,2005,21(6):622-624. |
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| 作者姓名： | 熊南翔 赵洪洋 张方成 |
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| 作者单位： | 华中科技大学同济医学院,附属协和医院神经外科,武汉,430022 |
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| 基金项目： | 国家自然科学基金（No.30471775）资助项目 |
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| 摘 要： | 为探讨Nogo-66受体在神经元生长锥中的定位及机能意义,本研究采用免疫荧光染色法,激光共聚焦显微镜下观察在原代培养小脑颗粒细胞生长锥的表达及其定位特征。结果发现,Nogo-66受体密集分布在细胞质和胞膜、神经突起内,延伸至生长锥体部C区和P区内,P区密度更高。Nogo-66受体定位于神经元生长锥中,提示Nogo-66受体可能参与轴突延伸和寻路的活动。
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| 关 键 词： | Nogo-66受体 Nogo-A 生长锥 表达 |
| 收稿时间： | 2005-03-14 |
| 修稿时间： | 2005年3月14日 |
EXPRESSION OF Nogo-66 RECEPTOR PROTEIN IN NERVE GROWTH CONES |
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| Xiong Nanxiang,Zhao Hongyang,Zhang Fangcheng.EXPRESSION OF Nogo-66 RECEPTOR PROTEIN IN NERVE GROWTH CONES[J].Chinese Journal of Neuroanatomy,2005,21(6):622-624. |
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| Authors: | Xiong Nanxiang Zhao Hongyang Zhang Fangcheng |
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| Abstract: | To investigate the expression and functional significance of Nogo-66 receptor in nerve growth cones. We observed the expression and location of Nogo-66 receptor in the nerve growth cones of primarily cultured cerebellar granule ceils by using immunofluorescent method with laser scanning conforcal microscope. The results showed that Nogo-66 receptor was intensely distributed in the cytoplasma, membrane, nerve process, and elongated to C domain and P domain of nerve growth corse body, the distribution intensity in P domain was higher than others. The results demonstrated that Nogo-66 receptor is located in growth cones, which indicates that Nogo-66 receptor may be involved in the elongation of axons. |
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| Keywords: | Nogo-66 receptor Nogo-A growth cones expression |
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