糖尿病视网膜病变黄斑无血管区图像定量研究

目的：研究糖尿病视网膜病变diabetic retinopathy，DR)患者黄斑无血管区(foveal avascualr zone,FAZ)的大小与形态可发生的改变。 方法：运用计算机图像处理系统，对糖尿病视网膜病变98只眼和健康人120只正常眼的眼底荧光血管造影(fundus fluorescein angiography,FFA)负片进行定量研究．测量FAZ面积与视盘面积的比值。 结果：DR组的FAZ面帜与视盘面积的比值显著大于正常对照组；且增值型DR组的FAZ面积与视盘面积的比值显著大于单纯型DR组．在DR组中，有35只眼的FAZ形态不规则，边缘断裂，周围有微动脉瘤。 结论：DR可出现FAZ面积扩大、形态不规则和边缘断裂，其周围可有微动脉瘤。 （中华眼底病杂志，1995，11：229-231）

QUANTITATIVE STUDY OF FOVEAL AVASCULAR ZONE IN DIABETICRETINOPATHY BY COMPUTERIZED IMAGE ANALYSIS

PURPOSE:To study the abnormalities of the foveal avascular zone(FAZ)in Chi-nese patients with diabetic retinopathy of non-insulin dependent diabete;mellitus(NIDDM).METHODS: Fundus fluorescein angiograms(FFA)of 98 eyes with diabetic retinopathy and 120 nor-mal control eyes were studied by computerized image analysis system,and the ratio of the FAZ area to the optic disc area vvas calculated.RESULTS:Quantitatively,the ratio was significantly greater in eyes with diabetic retinopathy than in control eyes and greater in eyes with proliferative diabetic retinopathy than in eyes with background diabetic retinopathy.In our study,irregularity and disrup-tion of the capillary boundary of FAZ with microaneurysms scattered around the FAZ were seen in 35 eyes with diabetic retinopathy, CONCLUSIONS:The data indicated that diabetic retinopathy in NIDDM is characterized by an irregular,large FAZ with microaneurysms scattered around.