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Comparison of Transthoracic Contrast Echocardiography with High-Resolution Chest CT after Embolization of Pulmonary Arteriovenous Malformation
Affiliation:1. Division of Interventional Radiology, Department of Radiology, University of Pennsylvania, Philadelphia, Pennsylvania;2. Division of Cardiovascular Medicine, Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania;3. Hereditary Hemorrhagic Telangiectasia Center of Excellence, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania;4. Division of Translational Medicine and Human Genetics, Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania;5. Biostatistics Consulting Unit, Office of Nursing Research, School of Nursing, University of Pennsylvania, Philadelphia, Pennsylvania;1. Department of Radiology, Yale New Haven Health Bridgeport Hospital, Bridgeport, Connecticut;2. Division of Interventional Radiology, Department of Radiology and Biomedical Imaging, Yale School of Medicine, 333 Cedar St., New Haven, CT 06510;1. Department of Radiology, Mayo Clinic School of Medicine, Rochester, Minnesota;2. Department of Hematology, Mayo Clinic School of Medicine, Rochester, Minnesota;3. Department of Biostatistics, Mayo Clinic School of Medicine, Rochester, Minnesota;1. Department of Diagnostic and Interventional Radiology, Kwong Wah Hospital, Hong Kong;2. Department of Radiology, 2/F, Block B, Hong Kong Children’s Hospital, 1 Shing Cheong Rd, Kowloon Bay, Hong Kong;3. Division of Paediatric Cardiology, Department of Paediatrics and Adolescent Medicine, Hong Kong Children’s Hospital, Hong Kong
Abstract:PurposeTo compare postembolotherapy follow-up graded transthoracic contrast echocardiography (TTCE) and high-resolution computed tomography (CT) of the chest and to evaluate the use of graded TTCE in the early postembolic period.Materials and MethodsThirty-five patients (6 men and 29 women; mean age, 56 years; range, 27–78 years) presenting for postembolotherapy follow-up between 2017 and 2021 with concurrent high-resolution CT and graded TTCE were analyzed retrospectively. Untreated pulmonary arteriovenous malformations (PAVMs) with a feeding artery of ≥2 mm were considered treatable.ResultsNinety-four percent of patients (33 of 35) did not have treatable PAVMs on high-resolution CT. TTCE was negative for shunts (Grade 0) in 34% of patients (n = 12). Of patients with a TTCE positive for shunts (23 of 35, 66%), 83% had a Grade 1 shunt, 13% had a Grade 2 shunt, and 4% had a Grade 3 shunt. No patient with a Grade 0 or 1 shunt had a treatable PAVM on high-resolution CT. Of the 2 patients with PAVMs requiring treatment, one had a Grade 2 shunt and one had a Grade 3 shunt. TTCE grade was significantly associated with the presence of a treatable PAVM on high-resolution CT (P < .01).ConclusionsGraded TTCE predicts the need for repeat embolotherapy and does so reliably in the early postembolotherapy period. This suggests that graded TTCE can be utilized in the postembolotherapy period for surveillance, which has the potential to lead to a decrease in cumulative radiation in this patient population.
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