Anti-Obesity Effect of 6,8-Diprenylgenistein,an Isoflavonoid of Cudrania tricuspidata Fruits in High-Fat Diet-Induced Obese Mice |
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| Authors: | Yang Hee Jo Kyeong-Mi Choi Qing Liu Seon Beom Kim Hyeong-Jin Ji Myounghwan Kim Sang-Kyung Shin Seon-Gil Do Eunju Shin Gayoung Jung Hwan-Soo Yoo Bang Yeon Hwang Mi Kyeong Lee |
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| Affiliation: | 1.College of Pharmacy, Chungbuk National University, Cheongju, Chungbuk 28644, Korea; (Y.H.J.); (K.-M.C.); (Q.L.); (S.B.K.); (H.-S.Y.); (B.Y.H.);2.Laboratory Animal Research Center, Chungbuk National University, Cheongju, Chungbuk 28644, Korea; (H.-J.J.); (M.K.); (S.-K.S.);3.Wellness R&D Center, Univera, Inc., Seoul 05014, Korea; (S.-G.D.); (E.S.); (G.J.) |
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| Abstract: | Obesity, which is characterized by excessive fat accumulation, is associated with several pathological disorders, including metabolic diseases. In this study, the anti-obesity effect of 6,8-diprenylgenistein (DPG), a major isoflavonoid of Cudrania tricuspidata fruits was investigated using high fat-diet (HFD)-induced obese mice at the doses of 10 and 30 mg/kg for six week. The body weight of the DPG-treated groups was significantly lower compared to the HFD-treated group. In addition, fat accumulation in epididymal adipose tissue and liver was dramatically decreased in the HFD + DPG groups. The food efficiency ratios of the HFD + DPG groups were also lower compared to the HFD group with the same food intake. Metabolic parameters that had increased in the HFD group were decreased in the HFD + DPG groups. Further studies demonstrate that DPG efficiently reduces lipogenic genes by regulation of transcription factors, such as peroxisome proliferator-activated receptor γ (PPARγ) and CCAAT/enhancer-binding protein α (C/EBPα), and hormones, such as leptin and adiponection. DPG also regulates acetyl-CoA carboxylase (ACC) and hydroxy-3-methylglutaryl coenzyme A reductase (HMGCR) by AMP-activated protein kinase (AMPK) activation. Taken together, DPG is beneficial for the regulation of obesity, especially resulting from high fat intake. |
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| Keywords: | 6,8-Diprenylgenistein (DPG) Cudrania tricuspidata high-fat diet-induced obesity lipid profile AMPK |
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