Fat grafting in patients with cleft lip and palate: A systematic review |
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| Affiliation: | 1. Department of Oral and Maxillofacial Surgery, Pontifical University Catholic of Rio Grande do Sul and São Lucas Hospital of PUCRS, Porto Alegre, Brazil;2. Department of Oral and Maxillofacial Surgery, Universitat Internacional de Catalunya, Sant Cugat del Valle’s and Institute of Maxillofacial Surgery, Teknon Medical Centre, Barcelona, Spain;3. Oral and Maxillofacial Surgeon, Private Practice, Valencia, Spain;4. Department of Orthodontics, Cardenal Herrera-CEU Universidad de Valencia, Valencia, Spain;5. Division of Plastic and Reconstructive Surgery, Department of Surgery, Yale School of Medicine, New Haven, CT, USA;1. Faculty of Medicine, Lisboa University, Portugal;2. Instituto Português da Face, Lisboa, Portugal;3. Centre for Rapid and Sustainable Product Development, Polytechnic Institute of Leiria, Portugal;1. Dept of Oral and Maxillofacial Surgery, Indo-Bhutan Friendship Hospital, Thimphu, 11001, Bhutan;2. Dept of Oral and Maxillofacial Surgery, Command Military Dental Centre (Western Command), Chandimandir, India;3. Dept of Anesthesiology, Military Hospital, Jalandhar Cantt, Punjab, India;4. Department of Preventive & Social Medicine, Armed Forces Medical College, Pune, Maharashtra, India;1. Faculty of Dentistry, Cairo University, Cairo, Egypt;2. Faculty of Oral and Dental Medicine, Future University, Cairo, Egypt;1. Oxford University Hospitals & Oral & Maxillofacial Surgery Practice, Oxford, United Kingdom;2. Zurich University Dental School & Private Dental Practice, Zurich, Switzerland;3. Department of Morphology, Surgery and Experimental Medicine, University of Ferrara, Italy;4. Private Dental Practice, Wallingford, Oxfordshire, United Kingdom;5. Department of Oral Surgery, Oral Radiology and Oral Medicine, University Center for Dental Medicine Basel, University of Basel, Switzerland;1. Hospital Sírio Libanês, São Paulo, Brazil;2. Instituto Vita, São Paulo, Brazil |
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| Abstract: | This systematic review aims to compare different fat-grafting techniques for cleft lip and palate repair. A search was conducted in PubMed, Embase, Cochrane Library, gray literature and reference lists of selected articles. A total of 25 articles were included, 12 on closure of palatal fistula and 13 on cleft lip repair. The rate of complete resolution of palatal fistula ranged from 88.6% to 100% in studies with no control group, whereas in comparative studies patients receiving a fat graft showed better outcomes than those not receiving a graft. Evidence suggests that fat grafting can be indicated for the primary and secondary repair of cleft palate, with good results. The use of dermis-fat grafts in lip repair was associated with gains in surface area (11.5%), vertical height (18.5%–27.11%), and lip projection (20%). Fat infiltration was associated with increased lip volume (6.5%), vermilion show (31.68% ± 24.03%), and lip projection (46.71% ± 31.3%). The available literature suggests that fat grafting is a promising autogenous option for palate and fistula repair and for improvement of lip projection and scar aesthetics in patients with cleft. However, to develop a guideline, further studies are needed to confirm whether one technique is superior to the other. |
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| Keywords: | Cleft lip Cleft palate Oral fistula Fat grafting Systematic review |
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