BPSD Patterns in Patients With Severe Neuropsychiatric Disturbances: Insight From the RECAGE Study |
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| Institution: | 1. Université Paris Cité (EC, ML, CP, SS, JD, JH), UMR-S 1144, INSERM, Paris, France;2. Cognitive Neurology Center (EC, AF, ML, JD, JH, CP), AP-HP.Nord, Site Lariboisière Fernand-Widal, Paris, France;3. Université Paris Cité (SS, JD), Inserm U1153, Epidemiology of Ageing and Neurodegenerative diseases, Paris, France;4. Department of Geriatry (ML), AP-HP.Nord, Site Lariboisière Fernand-Widal, Paris, France;5. Alzheimer Centre Limburg (RH), School for Mental Health and Neuroscience, Department of Psychiatry and Neuropsychology, Faculty of Health, Medicine and Life Sciences, Maastricht University, Maastricht, The Netherlands;6. Fondazione Europea di Ricerca Biomedica (FERB Onlus) (SF), Gazzaniga, Italy;7. The Research Centre for Age-related Functional Decline and Disease (SB), Innlandet Hospital Trust, Ottestad, Norway;8. The Norwegian National Centre for Aging and Health (SB), Vestfold Hospital Trust, Tønsberg, Norway;9. Memory Clinic (GBF), Geneva University Hospitals, Geneva, Switzerland;10. Laboratory of Neuroimaging of Aging (LANVIE) (GBF), University of Geneva, Geneva, Switzerland;11. Geriatric Service-Cognitive Disorders and Dementia (AF), Department of Primary Care, Health Authority and Services of Modena, Modena, Italy;12. Greek Association of Alzheimer''s Disease and Related Disorders (GAADRD) (MT), Thessaloniki, Hellas, Macedonia Greece;13. First Department of Neurology, School of Medicine (MT), Aristotle University of Thessaloniki (AUTh), Hellas, Macedonia Greece;14. Department of Geriatric Psychiatry (LF), Central Institute of Mental Health; Medical Faculty Mannheim, University of Heidelberg, Heidelberg, Germany;15. Department of Psychiatry (OP), Charité Universitätsmedizin Berlin, Berlin, Germany;16. German Center for Neurodegenerative Diseases (DZNE) (OP), Berlin, Germany;17. Neurological Unit (PM), U.V.A. Centre, Humanitas Gavazzeni, Bergamo, Italy;18. Department of Neurology with neurosurgical activity and stroke unit (AC), ASST di Mantova, Mantova, Italy;19. Section of Gerontology and Geriatrics (PM), Department of Medicine and Surgery, University of Perugia, Perugia, Italy;20. Clinical Geriatrics (PM), NVS Department, Karolinska Institutet, Stockholm, Sweden;1. Center for Health Outcomes and Policy Research, University of Pennsylvania School of Nursing (VEH, MDM, AK-L), Philadelphia, PA;2. The Leonard Davis Institute of Health Economics, University of Pennsylvania (VEH, MDM), Philadelphia, PA;3. Center for Health Equity Research and Promotion, Corporal Michael J. Crescenz VA Medical Center (AK-L), Philadelphia, PA;1. Division of Epidemiology, Dalla Lana School of Public Health (DAH, LCR, SEB), University of Toronto, Toronto, ON, Canada;2. ICES (LCM, PP, PCA, LCR, JG, CJM, SEB), Toronto, ON, Canada;3. KITE Research Institute-Toronto Rehabilitation Institute (AI), University Health Network, Toronto, ON, Canada;4. Department of Psychiatry (AI), University of Toronto, Toronto, ON, Canada;5. Sunnybrook Research Institute (PCA, SEB), Toronto, ON, Canada;6. Institute of Health Policy, Management and Evaluation, Dalla Lana School of Public Health (PCA, SEB), University of Toronto, Toronto, ON, Canada;7. Institute for Better Health, Trillium Health Partners (LCR) , Mississauga, ON, Canada;8. Department of Laboratory Medicine and Pathobiology, Temerty Faculty of Medicine (LCR), University of Toronto, Toronto, ON, Canada;9. Vector Institute (LCR), Toronto, ON, Canada;10. Schools of Pharmacy and Public Health Sciences, University of Waterloo (CJM), Waterloo, ON, Canada;11. Women''s College Research Institute (SEB), Women''s College Hospital, Toronto, ON, Canada;1. Service of Old Age Psychiatry, Department of Psychiatry (BPM, AVG), Lausanne University Hospital (CHUV) and University of Lausanne, Prilly, Switzerland;2. Centre for Research in Psychiatric Epidemiology and Psychopathology, Department of Psychiatry (MPFS, SR, CLV, MP), Lausanne University Hospital and University of Lausanne, Prilly, Switzerland;3. Department of Internal Medicine (JV), Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland;1. Division of Geriatric Psychiatry, Department of Psychiatry, Brigham and Women''s Hospital (T.B., N.J.D.), Boston, MA;2. Harvard Medical School (N.J.D.), Boston, MA;1. Oklahoma State University Center for Health Sciences (WS), Tulsa, OK;2. Morgantown High School (MJC), Morgantown, WV |
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| Abstract: | ObjectiveBehavioral and psychological symptoms of dementia (BPSD) profiles vary depending on etiology in patients with mild-to-moderate BPSD. It is not known if similar differences exist in patients with severe BPSD.MethodsWe analyzed data collected at baseline in 398 patients with severe BPSD (NPI ≥ 32) and defined diagnosis of dementia (Alzheimer's disease AD] 297; frontotemporal dementia FTD] 39; Lewy body disease/Parkinsonian dementia LBD/PD] 31; and vascular dementia VD] 31) included in the European multicenter cohort RECAGE.ResultsMean total NPI was 52.11 (18.55). LBD/PD patients demonstrated more hallucinations, more anxiety and more delusions than patients with other dementia. FTD patients had less delusions and more disinhibition than patients with other neurodegenerative disorders. These profiles overlapped partially with those reported in the literature in patients with less severe symptoms.ConclusionPatients with severe BPSD display different and specific profiles of neuropsychiatric symptoms depending on dementia etiology. |
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