血尿酸和胰岛功能与2型糖尿病患者血液流变学相关性分析

目的探究血尿酸(UA)、胰岛功能与2型糖尿病(T2DM)患者血液流变学相关性。方法选取2018年1月至2018年12月在本院收治的176例T2DM患者作为研究对象,根据血液流变学分为血液黏度正常组(72例)、血液黏度升高组(104例)。检测、对比2组血清UA、胰岛功能空腹胰岛素(FINS)、空腹C肽(FCP)]水平,采用Logistic回归分析探究T2DM患者血液流变学改变影响因素,Pearson相关性分析血清UA、FINS、CP与血液流变学相关性。以是否发生微血管病变分为微血管病变者、无微血管病变者,对比2者血清UA、FINS、FCP水平,Pearson相关性分析血清UA、FINS、FCP水平与微血管病变关联性。结果①血液黏度升高组血清UA、FINS、FCP水平高于血液黏度正常组(P<0.05);②病程、血清UA、FINS、FCP水平是T2DM血液流变学改变的重要影响因素(P<0.05);③血清UA、FINS、FCP水平与血液流变学呈正相关(P<0.05);④微血管病变者血清UA、FINS、CP水平高于无微血管病变者(P<0.05);⑤血清UA、FINS、FCP水平与微血管病变呈正相关(P<0.05)。结论血清UA、FINS、FCP水平是T2DM患者血液流变学改变危险因素,与血液流变学改变、微血管病变呈正相关,动态监测上述血清指标水平,可为临床评估预后提供科学指导。

Correlation between serum uric acid,islet function and hemorheology in patients with type 2 diabetes

Objective To investigate the relationship between serum uric acid(UA),islet function and hemorheology in patients with type 2 diabetes mellitus(T2 DM). Methods 176 T2 DM patients admitted to our hospital from January 2018 to December 2018 were selected as research objects,according to hemorheology,they were divided into normal blood viscosity group(72 cases)and blood viscosity increased group(104 cases). The levels of serum UA and islet functionfasting insulin(FINS)and fasting C-peptide(FCP)]were detected and compared. Logistic regression analysis was used to investigate the influencing factors of hemorheology in patients with T2 DM. Pearson correlation analysis was performed on the correlation between serum UA, FINS, CP and hemorheology. The microvascular lesions were divided into those with microangiopathy and those without microangiopathy. The serum levels of UA,FINS and FCP were compared between the two groups. The correlation between serum UA,FINS and FCP levels and microangiopathy was analyzed by Pearson correlation. Results①Serum UA,FINS and FCP levels in the blood viscosity increased group were higher than those in the normal blood viscosity group(P<0.05).②Course of disease,serum UA,FINS and FCP levels are important influencing factors of T2 DM hemorheological changes(P<0.05).③Serum UA,FINS,FCP levels were positively correlated with hemorheology(P<0.05).④Serum UA,FINS,CP levels were higher in microvascular lesions than those without microvascular disease(P<0.05).⑤Serum UA,FINS and FCP levels were positively correlated with microangiopathy(P<0.05). Conclusion Serum levels of UA,FINS and FCP are risk factors for hemorheological changes in patients with T2 DM. They are positively correlated with changes in hemorheology and microvascular diseases. Dynamic monitoring of the above serum indicators can provide scientific guidance for clinical assessment of prognosis.