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A local subset of mesenchymal cells expressing the transcription factor Osr1 orchestrates lymph node initiation
Affiliation:1. Institute for Chemistry and Biochemistry, Freie Universität Berlin, 14195 Berlin, Germany;2. Institut Pasteur, Université Paris Cité, CNRS UMR 6047, Unit for Integrated Mycobacterial Pathogenomics, 75015 Paris, France;3. Institut Pasteur, Stem Cells & Development Unit, CNRS UMR 3738, Paris, France;4. Core Facility Genomics, Berlin Institute of Health at Charité, 10178 Berlin, Germany;5. Max Delbrück Center for Molecular Medicine in the Helmholtz Association, 10115, Berlin, Germany;6. Max Delbrück Center for Molecular Medicine, Department of Translational Tumor Immunology, 13125 Berlin, Germany;7. Uppsala University, Immunology Genetics and Pathology, 75237 Uppsala, Sweden;8. Aix-Marseille Université, CNRS UMR 7288, IBDM, 13009 Marseille, France;9. Max Planck Institute for Molecular Genetics, 14195 Berlin, Germany;10. Max Delbrück Center for Molecular Medicine, Department of Microenvironmental Regulation in Autoimmunity and Cancer, 13125 Berlin, Germany;1. Lydia Becker Institute of Immunology and Inflammation, School of Biological Sciences, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, University of Manchester, Manchester M13 9PT, UK;2. Trinity Health Kidney Centre, Trinity Translational Medicine Institute, Trinity College, Dublin D08 W9RT, Ireland;3. Division of Informatics, Imaging & Data Sciences, School of Health Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester M13 9PT, UK;4. Geoffrey Jefferson Brain Research Centre, Manchester Academic Health Science Centre, Northern Care Alliance NHS Group, University of Manchester, Salford M6 8HD, UK;5. JJP Biologics, Warsaw, Poland;6. Department of Pathology & Immunology, Washington University, St. Louis, MO 63110, USA;1. Infection and Immunity Program, Department of Biochemistry and Molecular Biology, Monash Biomedicine Discovery Institute, Monash University, Clayton, VIC 3800, Australia;2. Centre for Infectious Disease Control, National Institute for Public Health and the Environment (RIVM), Bilthoven, Utrecht 3721MA, the Netherlands;3. Division of Infection and Immunity, Cardiff University School of Medicine, University Hospital of Wales, Cardiff CF14 4XN, UK;4. Systems Immunity Research Institute, Cardiff University School of Medicine, University Hospital of Wales, Cardiff CF14 4XN, UK;5. Infectious Diseases and Immunology, Department of Biomolecular Health Sciences, Faculty of Veterinary Medicine, Utrecht University, Utrecht 3584CL, the Netherlands;1. Department of Microbiology, New York University Grossman School of Medicine, New York, USA;2. Department of Women’s and Children’s Health, Karolinska Institutet, Stockholm, Sweden;3. Department of Pharmacology, Yale School of Medicine, New Haven, CT, USA;4. Department of Neurology, Yale School of Medicine, New Haven, CT, USA;5. Department of Immunobiology, Yale School of Medicine, New Haven, CT, USA;6. Department of Immunology & Inflammation, Imperial College London, London, UK;7. Laura & Isaac Perlmutter Cancer Center, New York University Langone Health, New York, NY, USA;1. Department of Gastroenterology and Hepatology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands;2. Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands;3. Department of Pediatrics, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands;4. Department of Computer Science and Applied Mathematics, Weizmann Institute of Science, Rehovot, Israel;5. Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel;6. Diagnostic and Research Institute of Hygiene, Microbiology and Environmental Medicine, Medical University Graz, Graz, Austria;7. Center for Cancer Research, Medical University of Vienna, Wien, Austria;1. Department of Oncology UNIL CHUV, Ludwig Institute for Cancer Research, University of Lausanne, Lausanne, Switzerland;2. Swiss Institute of Bioinformatics (SIB), Lausanne, Switzerland;3. Agora Cancer Research Centre, Lausanne, Switzerland;4. Swiss Cancer Center Leman (SCCL), Lausanne, Switzerland;5. Department of Oncology UNIL CHUV, Ludwig Institute for Cancer Research, University Hospital of Lausanne, Lausanne, Switzerland;6. Center of Experimental Therapeutics, Department of Oncology, Centre Hospitalier Universitaire Vaudois (CHUV), Lausanne, Switzerland;7. School of Life Sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland;1. Experimental Immunology Branch, National Cancer Institute, NIH, Bethesda, MD, USA;2. Synapse and Neural Circuit Research Section, National Institute of Neurological Disorders and Stroke, NIH, Bethesda, MD, USA;3. Department of Pediatrics, Boston Children’s Hospital, Harvard Medical School, Boston, MA, USA
Abstract:
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  • Keywords:lymph nodes  initiation  mesenchymal  Osr1  retinoic acid  lymphatic vessel  CXCL13
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