Predictors of Improvement of Sarcopenia after Transjugular Intrahepatic Portosystemic Shunt Creation in Cirrhotic Patients |
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| Affiliation: | 1. Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China;2. Hubei Province Key Laboratory of Molecular Imaging, Wuhan, China;3. Department of Interventional Radiology, Zhongshan Hospital, Fudan University, Shanghai, China;4. Interventional Section, Shenzhen People’s Hospital, Second Clinical Medical College of Jinan University, First Affiliated Hospital of Southern University of Science and Technology, Shenzhen, China;5. Department of Radiology, West China Hospital, Sichuan University, Chengdu, China;6. Department of Interventional Radiology, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China;1. Department of Radiology, Section of Interventional Radiology, Northwestern Memorial Hospital, Chicago, Illinois;2. Department of Medicine, Section of Gastroenterology, Northwestern Memorial Hospital, Chicago, Illinois;3. Department of Surgery, Northwestern Memorial Hospital, Chicago, Illinois;1. Long Island Jewish Medical Center, Northwell Health System, Queens, New York;2. New York Institute of Technology College of Osteopathic Medicine, Old Westbury, New York;3. Zucker School of Medicine at Hofstra University/Northwell Health System, Hempstead, New York;4. Icahn School of Medicine at Mount Sinai Hospital, New York, New York;1. Department of Radiology, Kaiser Permanente Oakland Medical Center, Oakland, California;2. Department of Radiology, Kaiser Permanente Richmond Medical Center, Richmond, California;3. Department of Psychology, George Mason University, Fairfax, Virginia;1. Division of Vascular and Interventional Radiology, Department of Radiology, Medical College of Wisconsin, Milwaukee, Wisconsin;2. Department of Radiology, Medical College of Wisconsin, Milwaukee, Wisconsin;3. Department of Pathobiology, University of Pennsylvania School of Veterinary Medicine, Philadelphia, Pennsylvania;4. Division of Vascular and Interventional Radiology, Department of Radiology, University of California San Diego, La Jolla, California;1. Department of Radiology, University of Chicago Medical Center, University of Chicago, Chicago, Illinois;2. Division of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, University of Chicago Medical Center, University of Chicago, Chicago, Illinois;3. Hematology and Oncology, Department of Medicine, University of Chicago Medical Center, University of Chicago, Chicago, Illinois;4. Transplantation Institute, Department of Surgery, University of Chicago Medical Center, University of Chicago, Chicago, Illinois;5. Division of Transplantation and Advanced Hepatobiliary Surgery, University of Utah, Salt Lake City, Utah |
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| Abstract: | To investigate the risk factors affecting the improvement of sarcopenia after transjugular intrahepatic portosystemic shunt (TIPS) in cirrhotic patients, this study retrospectively analyzed the data of 111 cirrhotic patients with sarcopenia who underwent TIPS creation. Computed tomography–based measurement of skeletal muscle area was used to calculate skeletal muscle index (SMI) in all patients at baseline and 6 months after TIPS creation. Multivariate logistic regression analysis was used to identify independent risk factors, which showed a significant increase in 6-month post-TIPS SMI compared with that at baseline in both men and women (for both, P < .001). Pre-TIPS SMI (odds ratio [OR], 0.93; 95% CI, 0.87–0.99; P = .031) and change in portal pressure gradient (OR, 1.13; 95% CI, 1.03–1.24; P = .009) were found to be independent risk factors for experiencing substantial improvement in post-TIPS SMI. |
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