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Macrophage-mediated extracellular matrix remodeling controls host Staphylococcus aureus susceptibility in the skin
Affiliation:1. Cutaneous Leukocyte Biology Section, Dermatology Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, USA;2. Cutaneous Microbiome and Inflammation Section, Dermatology Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, USA;3. Cancer Research Technology Program, Single-Cell Analysis Facility, Frederick National Laboratory for Cancer Research, Frederick, MD, USA;4. Department of Biochemistry and Structural Biology, University of Texas Health Science Center, San Antonio, TX, USA;5. Cancer Informatics Branch, Center for Biomedical Informatics and Information Technology, National Cancer Institute, National Institutes of Health, Rockville, MD, USA;1. University of California, San Francisco, Department of Dermatology, San Francisco, CA 94143, USA;2. University of California, San Francisco, Biomedical Sciences Graduate Program, San Francisco, CA 94143, USA;3. University of California, San Francisco, Oral and Craniofacial Sciences Graduate Program, San Francisco, CA 94143, USA;4. University of California, Los Angeles, Department of Infectious Diseases, Los Angeles, CA 90095, USA;5. Department of Dermatology, Meyer Cancer Center, Englander Institute for Precision Medicine, Weill Cornell Medical College, New York, NY, USA;6. Immunology and Microbial Pathogenesis Program, Weill Cornell Medical College, New York, NY, USA;7. Department of Pathology, Immunology and Laboratory Medicine, Rutgers New Jersey Medical School, Newark, NJ 07103, USA;8. Center for Immunity and Inflammation, Rutgers New Jersey Medical School, Newark, NJ 07103, USA;1. MRC Laboratory of Molecular Biology, Cambridge CB2 0QH, UK;1. Division of Experimental Pathology, Institute of Tissue Medicine and Pathology, University of Bern, 3008 Bern, Switzerland;2. Graduate School for Cellular and Biomedical Sciences, University of Bern, 3012 Bern, Switzerland;3. Institute of Tissue Medicine and Pathology, University of Bern, 3008 Bern, Switzerland;4. Interfaculty Bioinformatics Unit and Swiss Institute of Bioinformatics, University of Bern, 3012 Bern, Switzerland;5. Institute for Immunology, University Medical Center Mainz, 55131 Mainz, Germany;6. Division of Rheumatology, Department of Medicine, University Hospital of Geneva, 1211 Geneva, Switzerland;1. Key Laboratory of Infection and Immunity of Shandong Province & Key Laboratory for Experimental Teratology of Ministry of Education, Shandong University, Jinan 250012, Shandong, P.R. China;2. Department of Immunology, School of Biomedical Sciences, Shandong University, Jinan 250012, Shandong, P.R. China;3. Department of Pathogenic Biology, School of Biomedical Sciences, Shandong University, Jinan 250012, Shandong, P.R. China;4. Department of Medicinal Chemistry, School of Pharmaceutical Sciences, Shandong University, Jinan 250012, P.R. China;1. Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA;2. Graduate Program in Microbiology and Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA;3. School of Medicine, Tsinghua University, Beijing, China;4. Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA;5. Institute of Infection, Inflammation, and Immunity, UPMC Children’s Hospital of Pittsburgh, Pittsburgh, PA, USA;6. Department of Medicine, University of Chicago, Chicago, IL, USA;7. Committee on Immunology, University of Chicago, Chicago, IL, USA;8. Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA;9. Department of Molecular Microbiology and Immunology, Oregon Health & Science University, Portland, OR, USA;10. Center for Systems Immunology, Departments of Immunology and Computational & Systems Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA;11. Farncombe Family Digestive Health Research Institute, Department of Medicine, McMaster University, Hamilton, ON, Canada;12. Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA;13. Health Sciences Mass Spectrometry Core, University of Pittsburgh, Pittsburgh, PA, USA;14. Department of Cell Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA;15. Cancer Immunology and Immunotherapy Program, UPMC Hillman Cancer Center, Pittsburgh, PA, USA;1. Department of Immunology and Center for Innate Immunity and Immune Disease, University of Washington, 750 Republican St., Seattle, WA 98109, USA
Abstract:
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  • Keywords:skin  hypodermis  macrophages  extracellular matrix  insulin-like growth factor 1  hyaluronic acid
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