Multi-Toxic Endpoints of the Foodborne Mycotoxins in Nematode Caenorhabditis elegans |
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| Authors: | Zhendong Yang Kathy S. Xue Xiulan Sun Lili Tang Jia-Sheng Wang |
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| Affiliation: | 1.Synergetic Innovation Center of Food Safety and Nutrition, School of Food Science, Jiangnan University, Wuxi, Jiangsu 214122, China; (Z.Y.); (X.S.);2.Department of Environmental Health Science, University of Georgia, Athens, GA 30602, USA; (K.X.); (J.S.W.) |
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| Abstract: | Aflatoxins B1 (AFB1), deoxynivalenol (DON), fumonisin B1 (FB1), T-2 toxin (T-2), and zearalenone (ZEA) are the major foodborne mycotoxins of public health concerns. In the present study, the multiple toxic endpoints of these naturally-occurring mycotoxins were evaluated in Caenorhabditis elegans model for their lethality, toxic effects on growth and reproduction, as well as influence on lifespan. We found that the lethality endpoint was more sensitive for T-2 toxicity with the EC50 at 1.38 mg/L, the growth endpoint was relatively sensitive for AFB1 toxic effects, and the reproduction endpoint was more sensitive for toxicities of AFB1, FB1, and ZEA. Moreover, the lifespan endpoint was sensitive to toxic effects of all five tested mycotoxins. Data obtained from this study may serve as an important contribution to knowledge on assessment of mycotoxin toxic effects, especially for assessing developmental and reproductive toxic effects, using the C. elegans model. |
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| Keywords: | aflatoxin B1 Caenorhabditis elegans deoxynivalenol fumonisin B1 mycotoxins T-2 toxin zearalenone |
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