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The orphan receptor Nur77 binds cytoplasmic LPS to activate the non-canonical NLRP3 inflammasome
Affiliation:1. Department of Immunology, School of Basic Medical Sciences, Peking University, Beijing 100191, China;2. NHC Key Laboratory of Medical Immunology, Peking University, Beijing 100191, China;3. Key Laboratory of Molecular Immunology, Chinese Academy of Medical Sciences, Beijing 100191, China;4. Department of Anesthesiology, Peking University Third Hospital, Beijing 100191, China;5. Department of Sports Medicine, Peking University Third Hospital, Beijing 100191, China;6. Beijing Key Laboratory of Sports Injuries, Institute of Sports Medicine of Peking University, Beijing 100191, China;7. CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China;1. Department of Biochemistry and Molecular Cell Biology, Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China;2. Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China;3. Shanghai Institute of Immunology, Department of Immunology and Microbiology, Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China;4. School of Pharmacy, Shanghai Jiao Tong University, Shanghai 200240, China;1. Lydia Becker Institute of Immunology and Inflammation, School of Biological Sciences, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, University of Manchester, Manchester M13 9PT, UK;2. Trinity Health Kidney Centre, Trinity Translational Medicine Institute, Trinity College, Dublin D08 W9RT, Ireland;3. Division of Informatics, Imaging & Data Sciences, School of Health Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester M13 9PT, UK;4. Geoffrey Jefferson Brain Research Centre, Manchester Academic Health Science Centre, Northern Care Alliance NHS Group, University of Manchester, Salford M6 8HD, UK;5. JJP Biologics, Warsaw, Poland;6. Department of Pathology & Immunology, Washington University, St. Louis, MO 63110, USA;1. Key Laboratory of Cell Proliferation and Differentiation of the Ministry of Education, School of Life Sciences, Peking University, Beijing 100871, China;2. Peking-Tsinghua Center for Life Sciences, Peking University, Beijing 100871, China;1. Champalimaud Foundation, Champalimaud Centre for the Unknown, Champalimaud Research, Lisbon, Portugal;1. Department of Biomedicine, Division of Experimental Virology, University of Basel, 4055 Basel, Switzerland;2. Experimental Immunology and Osteoarthritis Research, Department of Rheumatology and Clinical Immunology, Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, 10117 Berlin, Germany;3. Pitzer Laboratory of Osteoarthritis Research, German Rheumatism Research Center (DRFZ), a Leibniz Institute, 10117 Berlin, Germany;4. Department of Immunobiology, University of Lausanne, 1066 Epalinges, Switzerland;5. Department of Biomedicine, Bioinformatics Core Facility, University Hospital Basel, 4031 Basel, Switzerland;6. Swiss Institute of Bioinformatics, Basel, Switzerland;7. Department of Pathology and Immunology University of Geneva, Geneva, Switzerland;8. Department of Oncology, University of Lausanne, 1066 Epalinges, Switzerland;9. Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne, VIC 3000, Australia;10. Witten/Herdecke University (UW/H), Faculty of Health/School of Medicine, Stockumer Str. 10, 58453 Witten, Germany;11. Division of Animal Physiology and Immunology, School of Life Sciences Weihenstephan, Technical University of Munich, 85354 Freising, Germany;12. Division of Clinical Pathology, Geneva University Hospital, 1211 Geneva, Switzerland;1. QIMR Berghofer Medical Research Institute, Herston, Brisbane, QLD 4006, Australia;2. School of Biomedical Sciences, Faculty of Medicine, The University of Queensland, Brisbane, QLD 4072, Australia;3. Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Dhaka, Dhaka 1000, Bangladesh;4. School of Biomedical Sciences, Queensland University of Technology, Brisbane, QLD 4000, Australia;5. School of Biomedical Sciences and Pharmacy, Faculty of Health, University of Newcastle, Newcastle, NSW, Australia;6. University of Queensland Frazer Institute, Faculty of Medicine, The University of Queensland, Woolloongabba, Brisbane, QLD 4102, Australia;7. Australian Infectious Diseases Research Centre, The University of Queensland, Brisbane, QLD, Australia;8. Mater Research Institute, The University of Queensland, Translational Research Institute, Wolloongabba, Brisbane, QLD 4102, Australia;9. Hunter Medical Research Institute, Newcastle, NSW, Australia;10. Princess Alexandra Hospital, Brisbane, QLD, Australia;11. The School of Earth and Environmental Sciences, The University of Queensland, Brisbane, QLD 4072, Australia;12. Microba Life Sciences, Translational Research Institute, Woolloongabba, Brisbane, QLD 4102, Australia;13. Telethon Kids Institute, The University of Western Australia, Nedlands, WA 6009, Australia
Abstract:
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  • Keywords:Nur77  NLRP3  non-canonical inflammasome  LPS  caspase-11
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