Risk factors associated with Hepatitis E virus infection in kidney transplant recipients in a single tertiary Center in the United States |
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| Affiliation: | 1. Johns Hopkins University School of Medicine, Baltimore, MD, USA;2. Department of Health Policy and Management, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA;3. Department of Environmental Health Sciences, Johns Hopkins University, Baltimore, MD, USA;4. Division of Viral Hepatitis, National Center for HIV, Viral Hepatitis, STD and TB Prevention, CDC, Atlanta, GA, USA;1. Department of Lung Cancer Surgery, Tianjin Medical University General Hospital; Anshan Road No.154, Heping District, Tianjin 300052, China;2. Department of Pediatric Surgery, Tianjin Children''s Hospital, No.238 LongYan Road, Tianjin 300134, China;3. Department of Genetics, School of Basic Medical Sciences, Tianjin Medical University, Qixiangtai Road, No.22, Heping District, Tianjin 300070, China;1. Shandong Provincial Hospital Affiliated to Shandong First Medical University, Shandong, China;2. Department of Hematology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Shandong, China;3. Department of Hematology, Shandong Provincial Hospital, Shandong University, Shandong, China;1. Department of Organ Transplantation, Renmin Hospital of Wuhan University, Wuhan 430060, Hubei, PR China;1. Faculty of Engineering and Natural Sciences, Department of Molecular Biology and Genetics, Kütahya Health Sciences University, Turkey;2. Faculty of Medicine, Istanbul Health and Technology University, Istanbul, Turkey;3. Anadolu Health Center, Bone Marrow Transplantation Center, Kocaeli, Turkey |
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| Abstract: | BackgroundHepatitis E virus (HEV), the causative agent of hepatitis E, is a common but self-limiting disease. However, in immunosuppressed kidney transplant 47 recipients (KTRs), HEV infection can become chronic. We investigated risk factors associated with HEV infection among 271 KTRs at the Johns Hopkins Hospital transplanted between 1988 and 2012.MethodsHEV infection was defined as having positive anti-HEV IgM, anti-HEV IgG, or HEV RNA. The risk factors included: age at transplant, sex, hemodialysis/peritoneal dialysis, plasmapheresis, transfusions, community urbanization, and other socioeconomic factors. Logistic regression was used to determine independent risk factors associated with HEV infection.ResultsOut of 271 KTRs, 43 (16%) had HEV infection though not active disease. HEV infection in KTRs was associated with older age (≥45 years; OR = 4.04; 95% CI = 1.81–57 10.03; p = 0.001) and living in communities with low proportions of minorities (OR = 0.22; 95% 58 CI = 0.04–0.90; p = 0.046).ConclusionKTRs who had HEV infection may be at an increased risk of developing chronic HEV. |
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