哮喘患儿血清嗜酸性粒细胞阳离子蛋白改变及其意义

目的：评价变应性哮喘患儿血清嗜酸性粒细胞阳离子蛋白（S-ECP）水平改变及其意义。方法：测定25例哮喘发作期患儿糖皮质激素吸入治疗12周前后，及20例未予糖皮质激素吸入治疗的哮喘缓解期患儿S-ECP水平，并对发作期患儿S-ECP水平变化与血嗜酸性粒细胞计数（B-EOS）、肺功能一秒用力呼气量（FEV1）、一秒用力呼气量比用力肺活量（FEV1/FVC）及症状评分的关系作相关性分析。结果：哮喘发作组治疗后S-ECP水平较治疗前显著降低，与对照组（健康儿童10名）比较差异无显著性；哮喘缓解组S-ECP水平明显高于发作组治疗后，但明显低于发作组治疗前。哮喘发作组治疗前S-ECP水平变化与B-EOS无相关性，与FEV1、FEV1/FVC呈负相关，与症状评分呈正相关。结论：监测S-ECP水平可作为评价哮喘气道炎症程度、病情预后和指导抗炎治疗的有效指标。

Changes of Serum Eosinophil Cationic Protein and its Significance in Asthmatic Children

Objective To investigate serum eosinophil cationic protein(S|ECP) levels in allergic asthma and its clinical significance. Methods S|ECP from 25 asthma attacks before and after treatment with inhaled corticosteroids(continued for 12 weeks ), and 20 patients no taking inhaled corticosteroids in stable conditions were tested. Correlation of S|ECP with blood eosinophil count(B|EOS), lung function FEV-1, FEV-1/FVC and symptom score was studied in pre|treatment group of attacks, respectively. {Results} S|ECP levels in post|treatment group were significantly decreased, as compared with pre|treatment group, while there was no significant difference between S|ECP levels in post|treatment group and those in control. S|ECP levels in stable conditions were significantly higher than those in post|treatment group, but significantly lower than in pre|treatment group. S|ECP correlated well with FEV-1, FEV-1/FVC and symptom score, but poorly with B|EOS. Conclusion Monitoring of S|ECP levels may effectively act as a marker to evaluate airway inflammation and patient's condition, and as a guide for anti|{inflammation} therapy in asthma.;