高低剂量醛红叶酸合并氟脲嘧啶治疗晚期胃肠道癌

 本文观察了国产酸氢叶酸(CF)两种不同剂量(20mg/M²和200mg/M²)合并5-Fu静脉持续120小时滴注治疗晚期胃肠道癌52例的疗效.认为采用低剂量国产CF合并5-Fu联合化疗方案在临床上更合适,安全经济,有一定推广价值.

Comparing the treatment of advanced colorectal and gastric carcinomas with 5-FU and High or Low-dose homemade Leucovirin

Weconducted a clinical trial comparing LDCF (20 mg/m2/day x 5 days) to HDCF (200 mg/m:/day x 5 days) combined with 5-Fu (1000 mg/day x 5 days) by continuous intravenous infusionfor 120 hours in the treatment of advanced gastric and colorectal carcinoma. Fifty-two evaluablepatients entered into this trial. In the series of 31 patients with advanced gsstric carcinoma (1graded CR, 13 PR). the resPOnse rates for LDCF and HDCF patients were 50% and 41 %, respectively (p>0. 05). Of 20 patiems with colorectal cancer (3 attained a PR) the re8POnse rates forLDCF and HDCF patiensts were 18 % and 11 % respectively (p>0. 05). HDCF/5-Fu regimen wasnot superior to LDCF/5-Fu regimen. Main toxicities included stomatitis, phlebitis, diarrhea, skinrash, and mild myelosuppression. Stomatitis occured in HDCF group much higher (64. 9%) thanin LDCF group (24% ), Basing upon considerations of therapeutic effectiveness, tokicity, and const, the authors conclude from this trioal that optimal leucovorin dose is 20 mg/m'.