急性呼吸窘迫综合征肺容积减少的机制与肺开放策略的选择

急性呼吸窘迫综合征(ARDS)是各种肺内外病因引起的肺毛细血管内皮细胞和肺泡上皮细胞损伤,由此导致的急性非心源性低氧性呼吸衰竭。肺容积减少是ARDS最重要的病理生理改变之一,也是当前ARDS机械通气治疗的主要着眼点和难点。肺组织自身重量增加导致肺泡塌陷,肺泡水肿,心脏和腹腔导致的压迫性肺不张是ARDS患者肺容积减少的原因。肺容积减少机制导向性的肺开放策略有助于达到改善氧合和减少呼吸机相关肺损伤的最佳平衡。

Mechanism of the loss of lung volume and selection of open lung strategy in acute respiratory distress syndrome

Acute respiratory distress syndrome (ARDS) is the most severe form of acute lung injury,which is characterized by acute non-cardiac hypoxic respiratory failure that associated with damage of pulmonary capillary endothelial cells and alveolar epithelial cells.The loss of lung volume is not only the most important pathophysiological change,but also the focus and difficulty of mechanical ventilation.Main causes of the loss of lung volume include alveolar collapse due to its own weight,alveolar edema,as well as...