| 搭载后红曲霉菌突变株的染色体DNA随机扩增多态性分析研究 |
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| 引用本文： | 印红,陆伟,谢申猛.搭载后红曲霉菌突变株的染色体DNA随机扩增多态性分析研究[J].航天医学与医学工程,2004,17(5):374-376. |
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| 作者姓名： | 印红 陆伟 谢申猛 |
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| 作者单位： | 北京东方红航天生物技术有限公司,北京,100086;中国农科院生物技术所,北京,100081;中国空间技术研究院,空间生物实验室,北京,100081 |
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| 基金项目： | 军转民技术开发项目资助 (科工民 [2 0 0 2 ] 2 98) |
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| 摘 要： | 目的：研究太空诱变机理。方法：利用染色体DNA随机扩增多态性分析(RAPD)技术，对经“神舟”3号返回式飞船搭载的高产红曲霉菌进行DNA多态性分析。结果：突变株基因组DNA发生了改变。结论：突变株洛伐他汀产量的提高与其遗传基因的变异有关，太空诱变是通过改变搭载菌株的遗传基因而实现的。
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| 关 键 词： | 空间环境 搭载 红曲霉菌 基因突变 突变株 |
| 文章编号： | 1002-0837(2004)05-0374-03 |
Study on Space Flight-mutants of Monascus Purpureus Using Random Amplified Polymorphic DNA |
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| YIN Hong,LU Wei,XIE Shen-meng. Space Biology Lab,Chinese Academy of Space Technology,Beijing,China.Study on Space Flight-mutants of Monascus Purpureus Using Random Amplified Polymorphic DNA[J].Space Medicine & Medical Engineering,2004,17(5):374-376. |
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| Authors: | YIN Hong LU Wei XIE Shen-meng Space Biology Lab Chinese Academy of Space Technology Beijing China |
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| Institution: | YIN Hong,LU Wei,XIE Shen-meng. Space Biology Lab,Chinese Academy of Space Technology,Beijing,100081,China |
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| Abstract: | Objective To study the mechanism of microbial mutation in aerospace. Method Random Amplified Polymorphic DNA (RAPD) was used to analyze the polymorphism of high Lovastatin-producing mutants. Result Variations occurred in genomes of these mutants. Conclusion The high Lovastatin producibility of the mutants is due to the variation of genomes, therefore the microbial mutation in the aerospace is achieved via the variation of hereditary genes in the microbes. |
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| Keywords: | space environments carry monascus purpureus gene mutation mutants |
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