| Protective Effect of Herba Dracocephali on Lipoperoxidation Damage in Patients with Coronary Heart Disease |
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| 作者姓名： | Shui-xiang Yang Tian-de Li Xing-sheng Yang Xiu-fang Hong Min Zhou Wen-jie Liu |
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| 作者单位： | Yang Shui-xiang (杨水祥); Li Tian-de (李天德); Yang Xing-sheng (杨兴生)(Department of Cardiology，The General Hospital of PLA，Beijing 100853)Hong Xiu-fang (洪秀芳); Zhou Min (周明); Liu Wen-jie (刘文杰)(Dept. of Cardiology，Xinjiang Medical College，Xi |
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| 摘 要： | ＰｒｏｔｅｃｔｉｖｅＥｆｆｅｃｔｏｆＨｅｒｂａＤｒａｃｏｃｅｐｈａｌｉｏｎＬｉｐｏｐｅｒｏｘｉｄａｔｉｏｎＤａｒｎａｇｅｉｎＰａｌｉｅｎｔｓｗｉｔｈＣｏｒｏｎａｒｙＨｅａｒｔＤｉｓｅａｓｅＹａｎｇＳｈｕｉ－ｘｉａｎｇ（杨水祥）；ＬｉＴｉａｎ－ｄｅ（李...
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Protective effect of herba dracocephali on lipoperoxidation damage in patients with coronary heart disease |
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| Authors: | Shui-xiang Yang Tian-de Li Xing-sheng Yang Xiu-fang Hong Min Zhou and Wen-jie Liu |
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| Institution: | 1. Department of Cardiology, The General Hospital of PLA, 100853, Beijing
2. Dept. of Cardiology, Xinjiang Medical College, 830000, Xinjiang
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| Abstract: | In order to study the effects of Herba Dracocephali (HD) in treating coronary heart disease(CHD) and antiperoxidative damage. 40 patients of CHD were treated with HD and the changes ot plasma su-peroxide dismutase (SOD) , lipid peroxide (LPO) , thromboxane B2 (TXB2) and 6-keto-prostaglandin F1 (6-keto-PGF1 ) as well as platelet LPO (PL-LPO) , SOD (PL-SOD) and selenium-glutathion peroxidase (SGP)were measured before and after treatment. Results showed that TXB2 , LPO and PL-LPO increased, whileSOD, PL-SOD decreased signiticantly in patients. After treatment by HD, the TXB2 , LPO, PL-LPO loweredand 6-keto-PGF1 , SOD, PL-SOD and SGP elevated obviotjsly. Electron microscopy showed that the ultra-structore of platelets improved and the activity ot adenylate cyclase increased markedly. The results suggest-ed that HD is a traditional Chinese herbal antioxidant and is hopeful tor treating CHD. |
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| Keywords: | Herba Dracocephali coronary heart disease Platelet Thromboxane A2 |
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