| 薄层色谱法测定注射用氨酪酸中的有关物质及配伍稳定性 |
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| 引用本文： | 薛梅妍,王东凯,纪标,隋志红,刘威,徐飒.薄层色谱法测定注射用氨酪酸中的有关物质及配伍稳定性[J].中国生化药物杂志,2006,27(2):89-91. |
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| 作者姓名： | 薛梅妍 王东凯 纪标 隋志红 刘威 徐飒 |
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| 作者单位： | 1. 沈阳药科大学,药剂系,辽宁,沈阳,110016
2. 沈阳沃森药物研究所,辽宁,沈阳,110016 |
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| 摘 要： | 目的采用薄层色谱法测定注射用氨酪酸中的有关物质及配伍稳定性。方法以正丁醇-水-冰醋酸(5∶2∶1)为展开剂,在硅胶G薄层板上展开,用茚三酮的丙酮溶液显色后观察。结果确定了氨酪酸有关物质限度,及其与3种输液配伍的稳定性。结论该法简便、灵敏、准确,可作为注射用氨酪酸有关物质及配伍稳定性的快速测定。
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| 关 键 词： | 氨酪酸 薄层色谱法 有关物质 配伍稳定性 |
| 文章编号： | 1005-1678（2006）02-0089-03 |
| 收稿时间： | 2005-06-09 |
| 修稿时间： | 2005-08-24 |
Study on the determination of related substances and compatible stability in aminobutyric acid for injection by thin-layer chromatography |
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| XUE Mei-yan,WANG Dong-kai,JI Biao,SUI Zhi-hong,LIU Wei,XU Sa.Study on the determination of related substances and compatible stability in aminobutyric acid for injection by thin-layer chromatography[J].Chinese Journal of Biochemical Pharmaceutics,2006,27(2):89-91. |
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| Authors: | XUE Mei-yan WANG Dong-kai JI Biao SUI Zhi-hong LIU Wei XU Sa |
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| Institution: | 1. Department of Pharmaceutics of Shenyang Pharmaceutical University, 2. Shenyang Watson Pharmaceutical Institute, Shenyang 110016, China |
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| Abstract: | PurposeTo control qualitatively the related substances and compatible stability in aminobutyric acid for injection by thin-layer chromatography(TLC).MethodsExpanding reagent: butanol-water-acetic acid glacial(5∶2∶1),stationary phase: G silicon gel and colorate reagent: dissolve ninhydrin in acetone.ResultsThe impurity limit of aminobutyric acid was obtained.It is compatible stability with three transfusion.ConclusionThis method is simple,sensitive and accurate.It can be usedt for the rapid quality control of the related substances and compatible stability in aminobutyric acid for injection. |
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| Keywords: | aminobutyric acid thin-layer chromatography related substances compatible stability |
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