| 注射用兰索拉唑与常用输液的配伍稳定性 |
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| 引用本文： | 杨艳,李冰,孙英华,方金玲,何仲贵.注射用兰索拉唑与常用输液的配伍稳定性[J].中国新药杂志,2007,16(10):794-796. |
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| 作者姓名： | 杨艳 李冰 孙英华 方金玲 何仲贵 |
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| 作者单位： | 沈阳药科大学药学院,沈阳,110016 |
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| 摘 要： | 目的：研究注射用兰索拉唑与4种常用输液配伍的稳定性。方法：采用HPLC法考察与4种输液按临床应用配伍，干室温条件下，考察12h内pH值，外观和含量的变化情况。结果：在室温条件下，与生理氯化钠溶液配伍后，6h内基本稳定，与10％葡萄糖，5％葡萄糖氯化钠和5％葡萄糖配伍后，随时间延长，含量分别降至97．5％，97．6％．98．0％。结论：注射用兰索拉唑可与生理氯化钠溶液配伍使用，但是应在4h内用完。
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| 关 键 词： | 高效液相色谱法 注射用兰索拉唑 稳定性 |
| 文章编号： | 1003-3734（2007）04-0794-03 |
| 收稿时间： | 2006-04-10 |
| 修稿时间： | 2006-04-10 |
Compatibility of lansoprazole for injection with four infusion solutions |
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| YANG Yan,LI Bing,SUN Ying-hua,FANG Jin-ling,HE Zhong-gui.Compatibility of lansoprazole for injection with four infusion solutions[J].Chinese Journal of New Drugs,2007,16(10):794-796. |
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| Authors: | YANG Yan LI Bing SUN Ying-hua FANG Jin-ling HE Zhong-gui |
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| Institution: | School of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016, China |
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| Abstract: | Objective:To evaluate the compatibility of lansoprazole for injection with four kinds of infusion solutions.Methods:Lansoprazole was extemporaneously compounded with 4 infusion solutions, respectively.The stability of the mixtures was then characterized in respect of the color,clarity,pH and concentration under room temperature for 12 h by HPLC.Results:The lansoprazole for injection in nor- mal saline solutions was stable for 6 h.The concentrations of lansoprazole for injection in 10% GS,5% GNS and 5% GS solutions got down to 97.5%,97.6% and 98.0%,respectively.Conclusion:Lanso- prazole for injection in 0.9% NS should be run out within 4 h after compounding. |
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| Keywords: | high performance liquid chromatography (HPLC) lansoprazole for injection stability |
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