细菌多药耐药基因组岛研究进展

多药耐药基因组岛是指细菌染色体上一段具有典型特征的基因簇,携带有多种耐药基因,决定细菌的多药耐药性;多药耐药基因组岛具有移动元件的特征,如G C百分比和密码子使用与宿主菌不同,常含移动基因,可以在同种甚至于不同种菌株间水平转移,加速了临床上多药耐药菌株的产生.目前在细菌中已发现两个较典型的多药耐药基因组岛:沙门菌属多药耐药基因组岛(SGI1岛)和鲍曼不动杆菌多药耐药基因组岛(AbaR1岛).研究细菌多药耐药基因组岛,可以了解多药耐药的分子基础、起源和进化;阐明多药耐药基因在菌株之间以及不同细菌和生态系统之间传播的机制.

Multi-drug-resistant genomic island of bacteria:a research progress

A multi-drug resistance genomic island of bacteria refers to the gene clusters section of bacterial chromosome with typical characteristics,on which there are many drug resistant genes determining the multi-drug resistance of bacteria.Multi-drug resistance genomic island has characteristics of mobile genetic elements such as different G C contents and codon usage.It usually contains mobile genes and can be transferred between homologous and even heterologous bacteria,which promotes the production of clinical multi-drug resistant strains.At present two typical multi-drug-resistant genomic islands have been found in bacteria:Salmonella multidrug resistant genomic island(SGI1 island)and Acinetobacter baumannii resistance genomic island(AbaR1 island).The knowledge about multi-drug-resistant genomic islands,their structure and their mobility is not only helpful in gaining a better understanding of molecular basis,the origin,evolution of multi-drug-resistance of bacteria but also can illuminate the transferring mechanism of multi-drug-genes between homologous and heterologous bacteria or even ecological systems.