| 硫氮酮治疗大鼠慢性缺氧时心肌和肺的病理变化 |
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| 引用本文： | 李元平,陈意生,许平庆,辛榕,谢增柱,刘福玉,高旭滨.硫氮酮治疗大鼠慢性缺氧时心肌和肺的病理变化[J].第三军医大学学报,1992(5). |
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| 作者姓名： | 李元平 陈意生 许平庆 辛榕 谢增柱 刘福玉 高旭滨 |
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| 作者单位： | 第三军医大学训练部病理学教研室 630038
(李元平，陈意生，许平庆，辛榕)，第三军医大学训练部高原医学研究室 630038
(谢增柱，刘福玉)，第三军医大学训练部高原医学研究室 630038(高旭滨) |
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| 摘 要： | 慢性缺氧时动物心肌和肺的主要病变为:心肌溶解坏死,线粒体增生、肿胀或溶解,毛细血管内皮细胞肿胀、饮泡增多、出现小管和呈绒毛状突起;肺小动脉管壁增厚、管腔狭窄,静脉血管周围结缔组织肿胀或见蛋白性物质等变化。硫氮(艹卓)酮治疗者,病变减少或变轻,毛细血管结构多较正常。文中对主要病变的发生机理,硫氮(艹卓)酮的作用进行了讨论。
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| 关 键 词： | 缺氧症 硫氮酮 肺/病理学 心肌/病理学 大鼠 |
Pathological changes of myocardium and lungs in chronic hy-poxia and therapeutic effects of dilthiazem in rats |
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| Li Yuangping,Chen Yisheng,Xie Zengzhu,et al.Pathological changes of myocardium and lungs in chronic hy-poxia and therapeutic effects of dilthiazem in rats[J].Acta Academiae Medicinae Militaris Tertiae,1992(5). |
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| Authors: | Li Yuangping Chen Yisheng Xie Zengzhu |
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| Abstract: | The main pathological changes of hypoxia in the myocardium were lysis or necrosis of the myocardium.hyperplasia or swelling of myocardial mitochondria,and swelling.increase of pinocytic vesicles in number,and appearance of tubules and villus-like eminences in the endothelial cells of myocardial capillaries:And those in the lungs were thickening of the wall and narrowing of the lumen of pulmonary arterioles,and swelling or appearance of proteinous material in the connec- tive tissue around pulmonary venules.After the treatment with dilthiazem.the pathological lesions were decreased in number or diminished in severity.In addition,the pathological mechanisms of hy-poxia and the therapeutic efficacy of dilthiazem were discussed. |
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| Keywords: | anoxia dilthiazem lung/PA myocardium/PA rats |
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