绝经后患者焦虑、抑郁状态对骨质疏松和生活质量的影响

目的了解骨质疏松症与焦虑、抑郁状态的相关性。方法选取来我院门诊就诊和住院的绝经后骨质疏松患者74例和非骨质疏松患者76例,采用综合性医院焦虑抑郁量表和健康状况调查问卷对其焦虑、抑郁状态及生活质量进行评估,同时采用RIA方法测定雌二醇、睾酮、孕酮、促卵泡素和促黄体生成素水平。结果骨质疏松组患者血清E2水平较对照组降低,差异有显著性(P=0.020),而骨质疏松组FSH较对照组有所升高,差异有显著性(P=0.024),骨质疏松患者的焦虑分、抑郁分均显著高于对照组,差异均有显著性(P<0.01)。骨质疏松患者的生活质量显著低于对照组,8个纬度分值均显著高于对照组,差异均有显著性(P<0.01)。结论焦虑、抑郁状态也是绝经后骨质疏松的危险因素,对这部分患者进行有针对性的心理咨询和干预治疗也是非常必要的。

Effect of anxiety and depression state with postmenopause women on osteoporosis and the quality of life

ObjectiveTo investigate the effect of anxiety and depression on patients with osteoporosis.Methods 74 osteoporosis patients and 76 healthy women in patient and out-patient department were assessed with the short-form-36 health survey(SF-36) as well as the hospital anxiety and depression scale(HAD). RIA method was used to observe the levels of Estradiol, Testosterone, Progesterone, Follicle-stimulating hormone and Luteinizing hormone.ResultsThe levels of serum E_2 in the osteoporosis patients were significantly lower than the control group(P=0.020). Compared with the control group, the levels of serum FSH in osteoporosis patients were increased (P=0.024). Both the prevalence of the negative emotions and HADs score were significantly higher in osteoporosis patients than the control group (P<0.01). The quality of life in osteoporosis patients was much poorer than that of the control group, which could be shown from the deceased scroes 8 related aspects in the investigating group(P<0.01).ConclusionsAnxiety and depression are also the most important risk factors to post-menopause osteoporosis. Effective psychological consultation and treatment are necessary for those osteoporosis patients.