| 基于Plackett-Burman设计和Box-Behnken响应面法优化鼻鼽颗粒一步制粒工艺 |
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| 引用本文： | 张艳军,刘莉莉,胡军华,吴云,晁恩祥,萧伟. 基于Plackett-Burman设计和Box-Behnken响应面法优化鼻鼽颗粒一步制粒工艺[J]. 中国中药杂志, 2015, 40(22): 4406-4410 |
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| 作者姓名： | 张艳军 刘莉莉 胡军华 吴云 晁恩祥 萧伟 |
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| 作者单位： | 江苏康缘药业股份有限公司, 江苏连云港 222001;中药制药过程新技术国家重点实验室, 江苏连云港 222001;中药提取精制新技术重点研究室, 江苏连云港 222001,江苏康缘药业股份有限公司, 江苏连云港 222001;中药制药过程新技术国家重点实验室, 江苏连云港 222001;中药提取精制新技术重点研究室, 江苏连云港 222001,江苏康缘药业股份有限公司, 江苏连云港 222001;中药制药过程新技术国家重点实验室, 江苏连云港 222001;中药提取精制新技术重点研究室, 江苏连云港 222001,江苏康缘药业股份有限公司, 江苏连云港 222001;中药制药过程新技术国家重点实验室, 江苏连云港 222001;中药提取精制新技术重点研究室, 江苏连云港 222001,北京中日友好医院, 北京 100029,江苏康缘药业股份有限公司, 江苏连云港 222001;中药制药过程新技术国家重点实验室, 江苏连云港 222001;中药提取精制新技术重点研究室, 江苏连云港 222001 |
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| 基金项目： | 国家"重大新药创制"科技重大专项(2013ZX09402203) |
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| 摘 要： | 首先,以颗粒的合格率为指标,采用Plackett-Burman设计筛选鼻鼽颗粒一步制粒的显著性影响因素;在此基础上,以颗粒的合格率和含水量为指标,通过Box-Behenken设计对影响一步制粒工艺的显著性因素进行进一步优化,实验数据进行多元线性回归和二项式拟合,应用响应面法对最佳工艺进行预测分析。鼻鼽颗粒一步制粒的最佳工艺条件为:进风温度85℃,进样速度33 r·min-1,浸膏相对密度1.10。采用Plackett-Burman和Box-Behnken设计响应面法优化鼻鼽颗粒一步制粒的工艺预测性好,优选出的工艺稳定可靠,为鼻鼽颗粒产业化生产提供了可靠依据。
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| 关 键 词： | 鼻鼽颗粒 Plackett-Burman设计 响应面法 Box-Behnken设计 一步制粒 |
| 收稿时间： | 2015-05-20 |
Optimization of one-step pelletization technology of Biqiu granules by Plackett-Burman design and Box-Behnken response surface methodology |
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| ZHANG Yan-jun,LIU Li-li,HU Jun-hu,WU Yun,CHAO En-xiang and XIAO Wei. Optimization of one-step pelletization technology of Biqiu granules by Plackett-Burman design and Box-Behnken response surface methodology[J]. China Journal of Chinese Materia Medica, 2015, 40(22): 4406-4410 |
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| Authors: | ZHANG Yan-jun LIU Li-li HU Jun-hu WU Yun CHAO En-xiang XIAO Wei |
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| Affiliation: | Jiangsu Kanion Pharmaceutical Co., Ltd., Lianyungang 222001, China;State Key Laboratory of New-tech for Chinese Medicine Pharmaceutical Process, Lianyungang 222001, China;The Key Laboratory for the New Technique Research of Traditional Chinese Medicine Extraction and Purification Lianyungang 222001, China,Jiangsu Kanion Pharmaceutical Co., Ltd., Lianyungang 222001, China;State Key Laboratory of New-tech for Chinese Medicine Pharmaceutical Process, Lianyungang 222001, China;The Key Laboratory for the New Technique Research of Traditional Chinese Medicine Extraction and Purification Lianyungang 222001, China,Jiangsu Kanion Pharmaceutical Co., Ltd., Lianyungang 222001, China;State Key Laboratory of New-tech for Chinese Medicine Pharmaceutical Process, Lianyungang 222001, China;The Key Laboratory for the New Technique Research of Traditional Chinese Medicine Extraction and Purification Lianyungang 222001, China,Jiangsu Kanion Pharmaceutical Co., Ltd., Lianyungang 222001, China;State Key Laboratory of New-tech for Chinese Medicine Pharmaceutical Process, Lianyungang 222001, China;The Key Laboratory for the New Technique Research of Traditional Chinese Medicine Extraction and Purification Lianyungang 222001, China,Department of Respiratory Medicine, China-Japan Friendship Hospital, Beijing 100029, China and Jiangsu Kanion Pharmaceutical Co., Ltd., Lianyungang 222001, China;State Key Laboratory of New-tech for Chinese Medicine Pharmaceutical Process, Lianyungang 222001, China;The Key Laboratory for the New Technique Research of Traditional Chinese Medicine Extraction and Purification Lianyungang 222001, China |
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| Abstract: | |
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| Keywords: | Biuqiu granules Plackett-Burman design response surface methodology Box-Behnken design one-step pelletization |
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