樊瑞红教授通补并用法治疗慢性心力衰竭

目的:总结樊瑞红教授通补并用法治疗慢性心力衰竭经验,观察其创立的通补并用的通补心宝汤治疗慢性心力衰竭的临床疗效和安全性。方法:将76例慢性心力衰竭患者随机分为治疗组38例和对照组38例。对照组予常规西药治疗,治疗组在此基础上加服通补心宝汤,28 d为1个疗程。观察治疗前后两组心功能、中医证候积分、射血分数,6 min步行试验,N末端脑钠肽(NT-pro BNP)情况。同时记录治疗期间不良反应。结果:治疗组心功能疗效总有效率为78.95%,优于对照组的60.53%(P0.05)。治疗组中医证候疗效总有效率为81.58%,明显优于对照组的55.26%(P0.01)。两组患者射血分数,6 min步行距离,NT-pro BNP比较,治疗组疗效优于对照组(P0.05)。两组均无严重不良反应发生。结论:通补并用法治疗慢性心力衰竭效果较好,通补心宝汤结合西医治疗慢性心力衰竭疗效优于单纯西医治疗。

Professor FAN Rui-hong's Method of Tong-bu on Treatment of Chronic Heart Failure

Objective: To summarize Professor FAN Rui-hong's experience of Tong-bu method on the treatment of chronic heart failure. To observe the clinical thereapeutic effect and safety on chronic heart failure(CHF) treated with self-made Tongbu Xinbao decoction of traditional Chinese medicine(TCM) of having the efficacy of Tong-bu. Method: Totally 76 cases of chronic heart failure were randomized into treatment group of 38 cases and control group of 38 cases.The control group was given routine western therapy and the treatment group was added with Tongbu Xinbao decoction of TCM.One treatment course lasted for 28 days.The heart function and the Chinese medicine syndrome scores and left ventricular ejection fraction and the distance in 6 minutes walking test and N-terminal pro-brain natriuretic peptide (NT-proBNP) were observed in both groups before and after treatment.The side effect was observed. Result: After treatment, the total effective rate of the heart function of the treatment group and the control group was 78.95% and 60.53% respectively, with significant difference between groups (P<0.05).The total effective rate of the Chinese medicine syndrome scores was significantly higher in treatment group (81.58%) than in control group (55.26%, P<0.01). The treatment group was better than the control group with improving the left ventricular ejection fraction and the distance in 6 minutes walking test and decreasing the level of NT-proBNP(P<0.05). There was no serious adverse event in two groups. Conclusion: The effect of Tong-bu method on the treatment of chronic heart failure is satisfaction, the treatment of integrated Tongbu Xinbao decoction of TCM and western medicine on chronic heart failure is superior to routine western therapy.