| 猫视神经损伤减压手术模型的建立 |
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| 引用本文： | 丁见,杨华,张念凯.猫视神经损伤减压手术模型的建立[J].山东医大基础医学院学报,2009(3):75-76. |
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| 作者姓名： | 丁见 杨华 张念凯 |
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| 作者单位： | 青岛市黄岛区中医医院耳鼻咽喉科;青岛大学医学院附属医院耳鼻咽喉科; |
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| 摘 要： | 目的制作与鼻内镜下视神经减压手术治疗外伤性视神经病路径相近的视神经损伤、视神经减压手术动物模型。方法鼻内镜下开放20只家猫的蝶窦,于蝶窦外侧壁锤击视神经管,造成视神经管骨折,8 h后鼻内镜下行视神经管减压。损伤和减压前后均分别给予感光视觉诱发电位（P-VEP）检测。结果损伤时在鼻内镜下见视神经管骨折。损伤后P-VEP示潜伏期延长,振幅降低。减压后70%家猫的P-VEP潜伏期、振幅均有不同程度的恢复。结论该方法制作的视神经损伤和减压术动物模型,与人外伤所致的视神经损伤具有相近的生物学特性,是一种较理想的研究视神经损伤和减压手术的模型。
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| 关 键 词： | 视神经 猫 动物模型 内窥镜检查 |
Model establishment of optic nerve decompression surgery in cats |
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| DING Jian,YANG Hua,ZHANG Nian-kai.Model establishment of optic nerve decompression surgery in cats[J].Journal of Preclinical Medicine College of Shandong Medical University,2009(3):75-76. |
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| Authors: | DING Jian YANG Hua ZHANG Nian-kai |
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| Institution: | 1.Department of Otolaryngology;Huangdao District Hospital of TCM;Qingdao 266500;Shandong;China;2.Department of Otolaryngology;Affiliated Hospital of Medical Colledge of Qingdao University;Qingdao 266003;China |
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| Abstract: | Objective To establish an experimental cat model of optic nerve damage and optic nerve decompression similar to traumatic optic neuropathy by a transnasal endoscopic approach.Methods The sphenoidal sinus was opened and then fracture of the optic canal was made by transnasal endoscopy with a hammer in 20 domestic cats,and optic nerve decompression was made 8 hours later.Photo-visual evoked potential(P-VEP) was made at anterior and posterior optic nerve injuries. Results Fracture of the optic canal was observ... |
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| Keywords: | Optic nerve Cats Animal model Endoscopy |
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