| 慢性铅暴露对幼鼠海马CA1区长时程增强的影响 |
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| 引用本文： | Liu J,Shi L,Wan B,Li B. 慢性铅暴露对幼鼠海马CA1区长时程增强的影响[J]. 中华预防医学杂志, 2000, 34(1): 34-36 |
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| 作者姓名： | Liu J Shi L Wan B Li B |
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| 作者单位： | ：刘君澜（湛江市 广东医学院预防医学教研室 524023）;时利德（中国医科大学脑研究所神经生理室）;万伯健（中国医科大学公共卫生学院卫生毒理室） |
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| 摘 要： |
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| 关 键 词： | 铅暴露 海马CA1区长时程增强 记忆 幼鼠 |
| 修稿时间： | 1999-02-01 |
Effects of chronic exposure to lead on long-term potentiation in hippocampal CA1 area of young rats in vivo |
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| Liu J,Shi L,Wan B,Li B. Effects of chronic exposure to lead on long-term potentiation in hippocampal CA1 area of young rats in vivo[J]. Chinese Journal of Preventive Medicine, 2000, 34(1): 34-36 |
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| Authors: | Liu J Shi L Wan B Li B |
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| Affiliation: | Department of Preventive Medicine, Guangdong Medical College, ZhanJiang, 524023, China. |
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| Abstract: | OBJECTIVE: To study the effects of chronic exposure to lead on learning and memory function in young rats, based on the plasticity of their synapse function. METHODS: With method of extracellular glass microelectrode recording, effects of exposure to lead at different concentrations on long term potentiation (LTP) induction in hippocampal CA(1) area of young rats in vivo were observed. RESULTS: Incidence of LTP and mean amplitude increase after application of high frequency stimulus decreased, as blood lead in rats reached (3.28 +/- 0.88) micromol/L, even causing long term depression. To the exposed rats, their mean increase ratio in their population spike amplitudes after high-frequency stimulation correlated inversely with their brain lead load. CONCLUSION: Chronic lead exposure could damage in vivo LTP induction and maintenance in the CA(1) area in hippocampus of rats, and the severity of damage increased with the extent of exposure to lead. |
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