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| 首发抑郁症患者治疗前后基于体素的DTI研究 | |
| 引用本文： | 孙军,刘含秋,孙华平,张俊海,冯晓源,郭琴,施慎逊.首发抑郁症患者治疗前后基于体素的DTI研究[J].中国医学计算机成像杂志,2011,17(3). |
| 作者姓名： | 孙军 刘含秋 孙华平 张俊海 冯晓源 郭琴 施慎逊 |
| 作者单位： | 1. 南京医科大学附属南京第一医院放射科 2. 复旦大学附属华山医院放射科 3. 复旦大学附属华山医院精神科 |
| 基金项目： | 上海市科委，上海市功能磁共振成像重点实验室开放课题基金，国家自然科学基金 |
| 摘 要： | 目的:应用磁共振弥散张量成像(DTI)探讨首发抑郁症患者药物治疗前后脑白质异常的变化特点.方法:采用3.0T磁共振成像仪,对13例首发抑郁症患者(分别于治疗前及抗抑郁药物治疗8周后)和14例性别、年龄相匹配的正常志愿者进行DTI检查.运用SPM2分析软件,采用基于体素的分析方法,比较首发抑郁症患者药物治疗前后全脑弥散各向异性分数(FA)值的差异及变化.结果:首发抑郁症患者的右侧胼胝体膝部、内囊膝部、右侧下纵束所属部分区域FA值明显低于正常对照组(P＜0.001),经过药物治疗症状缓解后,FA值明显恢复(P＜0.001).结论:治疗有效的首发抑郁症患者脑白质的微观病理改变是可逆的;DTI可以动态观察抑郁症患者脑白质的微观病理改变. |
| 关 键 词： | 抑郁症 药物治疗 磁共振成像 弥散张量 |
White Matter Abnormalities and Changes in First- onset Major Depressive Disorder by Antidepressant Treatment Investigated with Voxel - based Diffusion Tensor Imaging |
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| SUN Jun,LIU Han-qiu,SUN Hua-ping,ZHANG Jun-hai,FENG Xiao-yuan,GUO Qin,SHI Shen-xun.White Matter Abnormalities and Changes in First- onset Major Depressive Disorder by Antidepressant Treatment Investigated with Voxel - based Diffusion Tensor Imaging[J].Chinese Computed Medical Imaging,2011,17(3). | |
| Authors: | SUN Jun LIU Han-qiu SUN Hua-ping ZHANG Jun-hai FENG Xiao-yuan GUO Qin SHI Shen-xun |
| Institution: | SUN Jun1,LIU Han-qiu1,SUN Hua-ping1,ZHANG Jun-hai1,FENG Xiao-yuan1,GUO Qin2,SHI Shen-xun21 Department of Radilogy,Huashan Hospital,Fudan University(Sun Jun,Now in Department of Radiology,Nanjing First Hospital,Nanjing Medical University)2 Department of Psychiatry,Fudan University12 Wulumuqi Middle Rd.,Shanghai 200040,P.R.C. |
| Abstract: | Purpose:To detect white matter abnormalities in patients with first-onset major depressive disorder(MDD) and identify changes caused by antidepressant treatment.Methods:Thirteen patients with first onset MDD and 14 normal age-matched volunteers underwent diffusion tensor imaging(DTI) and all the patients underwent scanning twice during an 8-week period.Fractional anisotropy(FA) maps were processed using SPM2 to make voxel-wise comparison of anisotropy in whole brain between the two groups.Results: Significa... |
| Keywords: | Depression Antidepressant Magnetic resonance imaging Diffusion tensor |
| 本文献已被 CNKI 万方数据 等数据库收录！ | |