| COX-2与VEGF在子宫内膜增生症及子宫内膜癌的表达及意义 |
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| 引用本文： | 陈丽艳,脱晋,郭秀娟.COX-2与VEGF在子宫内膜增生症及子宫内膜癌的表达及意义[J].中国当代医药,2013(7):37-39. |
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| 作者姓名： | 陈丽艳 脱晋 郭秀娟 |
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| 作者单位： | 辽宁省大连市妇产医院急诊科,辽宁大连116033 |
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| 摘 要： | 目的探讨COX-2与VEGF在子宫内膜癌发生发展中的意义。方法采用免疫组化的方法检测100例子宫内膜癌．90例子宫内膜增生症，30例正常增生期内膜中COX-2与VEGF的表达。结果COX-2在正常增生期内膜无表达，VEGF在正常子宫内膜中有偶见少量弱阳性表达，COX-2与VEGF在子宫内膜增生症中的三种组织类型单纯性、复杂性及不典型中的表达逐渐增高（P〈0．05），COX-2与VEGF在子宫内膜癌中的表达明显高于子宫内膜增生症及正常子宫内膜（P〈0．05）。结论COX-2与VEGF在子宫内膜癌的发生发展中可能起到促进作用。
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| 关 键 词： | 子宫内膜癌 子宫内膜增生症 环氧化酶-2 血管内皮生长因子 |
The expression and significance of COX-2 and VEGF in endometrial hyperplasia disease and endometrial adenocarcinoma |
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| Authors: | CHEN Liyan TUO Jin GUO Xiujuan |
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| Institution: | Emergency Department, Dalian Maternity Hospital of Liaoning Province, Dalian 116033, China |
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| Abstract: | Objective To explore the influence of COX-2 and VEGF in endometrial carcinoma in the development . Methods Expression of COX-2 and VEGF was examined by immunohistochemistryin 100 cases endometrial adeno-carcinomas, 90 cases endometrial hyperplasias and 30 cases normal endometrial. Results COX-2 had no expression in normal proliferative endometrium, occasionally a small amount weakly positive expression of VEGF in normal en- dometrium, three tissue types of COX-2 and VEGF in endometrial hyperplasia, simple, complex and atypical in the expression gradually increased （P 〈 0.05）, COX-2 and VEGF expression in endometrial cancer was significantly higher than that of endometrial hyperplasia and normal endometrial （P 〈 0.05）. Conclusion COX-2 and VEGF may play a role in promoting the development of endometrial cancer. |
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| Keywords: | Endometrial carcinoma Endometrial hyperplasia Cyclooxygenase-2 Vascular endothelial growth factor |
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