中老年人心血管疾病与年龄相关性白内障的关系

目的:评价人群心血管疾病对年龄相关性白内障(age-related cataract,ARC)发生的影响。方法:采用回顾性病例对照研究方法,2009-09/2011-03对360例病例和匹配的360例对照进行了调查。主要的测量指标为心血管疾病(cardiovascular disease,CVD)与ARC关联的比值比(OR)及其相应的95%可信区间(CI)。采用自行设计的调查表对研究对象进行调查。结果:病例组与对照组之间,年龄、职业,以及居住地的差异无统计学意义。调整了多种潜在性混杂因素后,空腹血糖受损的研究对象和已确诊的糖尿病患者发生ARC的危险性分别升高了62.4%和69.8%(OR=1.624,95%CI:1.068～2.553,P=0.007;OR=1.698,95%CI:1.412～2.719,P=0.009);高血压患者与ARC的关联性较强(OR=1.431,95%CI:1.098～1.997,P=0.007);现行吸烟者和现行饮酒者发生ARC的危险性也显著增高(OR=1.712,95%CI:1.312～2.344,P=0.010;OR=1.912,95%CI:1.310～2.896,P=0.003)。结论:糖尿病、高血压、吸烟及饮酒可使发生ARC的危险性增加,最终导致ARC的发生。

Association between cardiovascular disease and age-related cataract in middle-aged and elderly men

AIM: To evaluate the influence of cardiovascular disease on age-related cataract(ARC).

METHODS: A retrospective case-control study of all the cases(years 2009.09-2011.03)(n=360)and 360 matched controls. The main outcome measures were the odds ratios(OR)and corresponding 95% confidence intervals(CI)of ARC. All subjects were interviewed using a structured interviewer-administrated questionnaire.

RESULTS:No difference was found in age, occupation, residence. After adjustment for multiple potential confounders, the risks of ARC for cases in fasting glucose impaired and diabetes increased 62.4% and 69.8%, respectively(OR=1.624, 95% CI:1.068-2.553, P=0.007; OR =1.698, 95% CI:1.412-2.719, P=0.009). The risk of ARC in hypertension significantly increased(OR=1.431, 95% CI:1.098-1.997, P=0.007). Current smoking and drinking were risk factors of ARC(OR=1.712, 95% CI:1.312-2.344, P=0.010; OR=1.912, 95% CI:1.310-2.896, P=0.003).

CONCLUSION: Diabetes, hypertension, smoking, and drinking have higher risks of ARC, and eventually lead to the occurrence of ARC.