昂丹司琼对全麻腹腔镜胆囊切除术患者术后恶心呕吐的影响及护理

目的研究术中静脉注射昂丹司琼对腹腔镜胆囊切除术患者术后恶心呕吐（PONV）的影响及护理。方法择期行全麻腹腔镜胆囊切除术患者90例，将患者随机分为3组各30例：小剂量昂丹司琼组（O1组），切皮前静脉注射4mg昂丹司琼；大剂量昂丹司琼组（O2组），切皮前静脉注射8mg昂丹司琼；对照组（C组），切皮前静脉注射生理盐水。所有注射液体均稀释为4ml。观察术后24h发生恶心呕吐的例数及程度。结果与C组比较，O1组与O2组发生PONV的例数减少且程度减轻，P〈0．05；O1组与O2组之间比较差异无统计学意义，P〉0．05。结论术中静脉注射昂丹司琼可以减少腹腔镜胆囊切除术后患者的恶心呕吐。

Effect of Ondansetron on postoperative nausea and vomiting in patients undergoing iaparoscopic cholecystectomy with general anesthesia

Objective To investigate the influence of Ondansetron on postoperative nausea and vomiting （PONV） in patient undergoing laparoscopic cholecystectomy with general anesthesia and the nursing care. Methods Ninety patients undergoing laparoscopic cholecystectomy with general anesthesia were randomly divided into 3 groups （n=30）： low-dose Ondansetron group （O1 group） received 4 mg Ondansetron before section, high-dose Ondansetron group （O2 group） received 8 mg Ondansetron before section and the control group（C group） received normal saline. All injections were diluted to 4 ml. The number and degree of nausea and vomiting was recorded during 24 h after operation. Results Number of patients with PONV in O1 group and O2 group were less than that of C group,P 〈 0.05,so was the PONV degree.No statistical difference was seen between O1 group and O2 group. Conclusion Intravenous injection of Ondansetron during operation can decrease the PONV in patient undergoing laparoscopic cholecystectomy with general anesthesia.