雷公藤多苷联合阿达木单抗治疗强直性脊柱炎的疗效分析

目的 探讨雷公藤多苷片联合阿达木单抗注射液治疗强直性脊柱炎患者的疗效.方法 回顾性选取强直性脊柱炎患者52例,根据其治疗方案分为联合组(n=25)和参照组(n=27).参照组采用40 mg的阿达木单抗注射液皮下注射治疗,隔周给药1次,共治疗3个月.联合组在参照组的基础上予以雷公藤多苷片口服治疗,20 mg/次,3次/d...

Efficacy of Tripterygium Wilfordii Polyglycoside Tablets Combined With Adalimumab in the Treatment of Ankylosing Spondylitis

Objective To explore the efficacy of tripterygium wilfordii polyglycoside tablets combined with adamumab injection in the treatment of ankylosing spondylitis. Methods A total of 52 patients with ankylosing spondylitis were retrospectively selected and divided into combined group(n =25) and reference group(n =27) according to their treatment plan. The control group was treated with 40 mg adamuzumab injection subcutaneously, once every other week for 3 months. Combined group was additionally given oral treatment of tripterygium wilfordii polyglycoside tablets, 20 mg/time, 3 times/day, for 3 consecutive months. The efficacy of the two groups was evaluated and compared. Serum levels of transforming growth factor-β(TGF-β), interleukin-6(IL-6), interleukin-17(IL-17) and interleukin-23(IL-23), C-reactive protein(CRP) and erythrocyte sedimentation rate(ESR) were detected and compared before and after treatment. The incidence of adverse reactions was statistically compared between the two groups. Results The effective rate in combination group was 96.00%(24/25), which was higher than that in reference group 70.37%(19/27), the difference was statistically significant(P < 0.05). There was no significant difference in the levels of inflammatory factors and erythrocyte sedimentation rate between 2 groups before treatment(P > 0.05). Compared with before treatment and between 2 groups after treatment, the levels of serum TGF-β, IL-6, IL-17 and IL-23, as well as the levels of CRP and ESR in patients were decreased, the difference was statistically significant(P < 0.05). Compared with the control group, the levels of serum TGF-β, IL-6, IL-17 and IL-23, plasma CRP level and ESR level in combined group were significantly lower after treatment, the difference was statistically significant(P < 0.05). There was no significant difference in the incidence of adverse reactions between two groups(P > 0.05). Conclusion Tripterygium wilfordii polyglycoside tablets combined with adamumab injection can effectively improve the curative effect and maintain the stability of immune internal environment in the treatment of ankylosing spondylitis, and it is safe and reliable.