美托洛尔联合坎地沙坦治疗冠心病并发慢性心力衰竭的效果

目的 探讨美托洛尔与坎地沙坦治疗冠状动脉粥样硬化性心脏病(简称为冠心病)并发慢性心力衰竭(简称为心衰)的效果.方法 92例研究对象均为2019年11月—2020年10月医院收治的冠心病并发慢性心衰患者,以随机数字表法将其划分为两组.两组均接受常规抗心衰治疗,对照组46例应用美托洛尔治疗,研究组在此基础上联合坎地沙坦治疗...

The Effect of Metoprolol and Candesartan in the Treatment of Coronary Heart Disease With Heart Failure

Objective To explore the effects of metoprolol and candesartan in the treatment of coronary atherosclerotic heart disease(abbreviated as coronary heart disease) and chronic heart failure(abbreviated as heart failure). Methods A total of 92 study subjects were all patients with coronary heart disease and chronic heart failure admitted to Second People’s Hospital of Heze City from November 2019 to October 2020. They were divided into two groups by a random number table method. Both groups were received routine anti-heart failure Treatment, 46 cases in the control group were treated with metoprolol, and the study group was combined with candesartan on this basis. To observe and compare the clinical efficacy, cardiac function indexes before and after treatment and cardiac biochemical markers,and adverse reactions. Results In the comparison of total effective rate, the result of the study group was 95.65%, the result of the control group was 80.43%, and the result of the study group was higher, the difference was statistically significant(P < 0.05). After treatment, the levels of LVESD and LVEDD in the study group were lower than those in the control group, the difference was statistically significant(P <0.01), the levels of LVEF were higher than those in the control group,the difference was statistically significant(P < 0.01), and the levels of MMP-9 and NT-proBNP were lower than those in the control group,the difference was statistically significant(P < 0.01). There was no significant difference in the incidence of adverse reactions between the two groups(P > 0.05). Conclusion The combination of metoprolol and candesartan has a definite effect in the treatment of coronary heart disease and heart failure, which can effectively improve the heart function of patients and is suitable for clinical promotion.