右美托咪定复合硬膜外麻醉对老年疝气手术患者应激反应指标、呼吸循环指标及认知功能的影响

目的 探讨右美托咪定复合硬膜外麻醉对老年疝气手术患者应激反应指标、呼吸循环指标及认知功能的影响.方法 选择2018年3月至2019年3月我院收治的130例老年疝气手术患者为研究对象,根据麻醉方式不同将其分为对照组和观察组,各65例.对照组接受常规硬膜外麻醉,观察组在对照组基础上给予右美托咪定复合硬膜外麻醉.比较两组的应...

Effects of dexmedetomidine combined with epidural anesthesia on stress response indexes,respiratory and circulatory indexes and cognitive function in elderly patients undergoing hernia surgery

Objective To investigate the effects of dexmedetomidine combined with epidural anesthesia on stress response indexes,respiratory and circulatory indexes and cognitive function in elderly patients undergoing hernia surgery.Methods A total of 130 elderly patients undergoing hernia surgery treated in our hospital from March 2018 to March 2019 were selected as the research objects.According to different anesthesia methods,the patients were divided into control group and observation group,with 65 cases in each group.The control group received routine epidural anesthesia,and the observation group was given dexmedetomidine combined epidural anesthesia on the basis of the control group.The stress response indexes,respiratory and circulatory indexes,cognitive function and postoperative recovery were compared between the two groups.Results At T₀,there were no significant differences in the levels of NE and Cor between the two groups(P>0.05);at T₁,T₂,T₃,T₄ and T₅,the levels of NE and Cor in the two groups were higher than those at T₀,and the differences were statistically significant(P<0.05);at T₁,T₂,T₃,T₄ and T₅,the levels of NE and Cor in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).At T₀,there were no significant differences in SpO₂ and RR between the two groups(P>0.05);at T₁,T₂,T₃,T₄ and T₅,there were no significant differences in SpO₂ and RR compared with those at T₀ in the observation group(P>0.05),but those were significantly lower than at T₀ in the control group(P<0.05);at T₁,T₂,T₃,T₄ and T₅,SpO₂ and RR in the observation group were higher than those in the control group,and the differences were statistically significant(P<0.05).Before operation,there were no significant differences in MMSE and MoCA scores between the two groups(P>0.05);7 d after operation,the MMSE and MoCA scores of the two groups were lower than those before operation,and the differences were statistically significant(P<0.05);7 d after operation,the MMSE and MoCA scores of the observation group were higher than those of the control group,and the differences were statistically significant(P<0.05).There were no significant differences in recovery time,extubation time and leaving recovery room time between the two groups(P>0.05);the sedation agitation score and FSS score of the observation group were lower than those of the control group,and the QoR-40 score was higher than that of the control group,and the differences were statistically significant(P<0.05).Conclusion Dexmedetomidine combined with epidural anesthesia in elderly patients undergoing hernia surgery can effectively alleviate the stress response,have no significant effect on respiratory circulation and cognitive function,and improve the postoperative recovery effect,which is worthy of popularization.