| 高效液相色谱法测定盐酸异丙嗪片含量 |
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| 引用本文： | 宋新康,刘志辉,严全鸿.高效液相色谱法测定盐酸异丙嗪片含量[J].解放军药学学报,2010,26(4):350-352. |
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| 作者姓名： | 宋新康 刘志辉 严全鸿 |
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| 作者单位： | 1. 广东省梅州市药品检验所,广东梅州,514071
2. 广东省药品检验所,广东广州,510182 |
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| 摘 要： | 目的建立高效液相色谱法测定盐酸异丙嗪片的含量。方法采用C18色谱柱,流动相为水〔用冰醋酸调节pH（2.25±0.05）-甲醇（51∶49〕,检测波长为254nm。结果盐酸异丙嗪在4.05～40.50μg/ml范围内有良好的线性关系,Y=115.767X＋14.409,r=0.9998（n=7）,平均回收率为100.7%,RSD为0.42%（n=9）。结论本方法分离良好,结果准确可靠,重复性好,可作为盐酸异丙嗪片的含量测定方法 。
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| 关 键 词： | 高效液相色谱法 盐酸异丙嗪片 含量测定 |
Determination of Promethazine Hydrochloride Tablets by High Performance Liquid Chromatography |
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| SONG Xin-kang,LIU Zhi-hui,YAN Quan-hong.Determination of Promethazine Hydrochloride Tablets by High Performance Liquid Chromatography[J].Pharmaceutical Journal of Chinese People's Liberation Army,2010,26(4):350-352. |
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| Authors: | SONG Xin-kang LIU Zhi-hui YAN Quan-hong |
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| Institution: | (①Institute for Drug Control of Meizhou,Meizhou 514071,China;②Institute for Drug Control of Guangdong,Guangzhou 510182,China ) |
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| Abstract: | Objective To establish a high performance liquid chromatography method to determine promethazine hydrochloride.Methods The high performance liquid chromatography method was used on C18 column.The mobile phase consisted of water（adjusted to pH2.25±0.05 by acetate）and methanol（51∶49）.The detection wavelength was set at 254 nm.Results There was a good linear relationship within the concentration range of 4.05-40.50 μg/ml（Y=115.767X＋14.409,r=0.9998,n=7）,The average recovery was 100.7% and RSD was 0.42%（n=9）.Conclusion The method has a good effect of separation,being accurate,reliable and applicable to determination of promethazine hydrochloride tablets. |
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| Keywords: | high performance liquid chromatography promethazine hydrochloride tablet determination |
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