舒胸巴布剂的渗透促进剂研究

目的探讨氮酮、丁香油两种渗透促进剂对舒胸巴布剂透皮渗透的影响。方法制备不同浓度氮酮、丁香油及不含渗透促进荆的舒胸巴布剂，以该巴布剂中的主要有效成分阿魏酸为考察指标，通过体外透皮试验，研究氮酮和丁香油的渗透促进作用。结果不同浓度的丁香油和氮酮均有渗透促进作用，丁香油优于氮酮，其最佳浓度为3％，最高增渗倍数为3．68倍。结论以阿魏酸累积渗透量为指标，选择3％丁香油作为舒胸巴布剂渗透促进剂最为适宜。

Study of Permeation Enhancers of Shuxiong Cataplasm

Objective To investigate the effect of two kinds of permeation enhancers, azone and clove bud oil, on transdermal permeation of Shuxiong cataplasm. Methods Cataplasm containing azone and clove bud oil, at different concentrations were prepared, with ferulic acid as the index, the role of enhancing permeation of azone and clove bud oil for the main active component were studied by in vitro permeation experiments. Results Both azone and clove bud oil at different concentrations could increase permeation. Clove bud oil was better than azone and the best concentration of Clove bud oil is 3%. Meanwhile, the permeation enhancing multiple of clove bud oil group was the highest which was 3.68. Conclusion With the cumulative permeation quantity of ferulic acid as the index, 3% clove bud oil is more suitable to act as a permeation enhancer of Shuxiong cataplasm.