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| 羟甲基烟酰胺分散片的研制 | |
| 引用本文： | 雍德卿,臧恒昌,翟光喜. 羟甲基烟酰胺分散片的研制[J]. 山东大学学报(医学版), 2003, 41(4): 451-452 |
| 作者姓名： | 雍德卿 臧恒昌 翟光喜 |
| 作者单位： | 1. 山东大学齐鲁医院 2. 山东大学康诺制药厂 3. 山东大学药学院 |
| 摘 要： | 目的：研制羟甲基烟酰胺分散片。方法：以崩解时间为指标。比较几种崩解剂的作用，以正交试验设计确立最佳处方，并与普通片进行体外溶出度比较。结果：崩解剂以低取代羟丙纤维素(L-HPC)效果最优，最佳处方崩解时间为78．9S，溶出速度远大于普通片。结论：所研制的羟甲基烟酰胺分散片溶出迅速。 |
| 关 键 词： | 烟酰胺 剂型 正交设计 分散片 |
| 文章编号： | 1671-7554(2003)04-0451-02 |
| 修稿时间： | 2003-02-23 |
Preparation of dispersible nicotinylmethylmthylamidi tablets |
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| YONG De-qing,ZANG Heng-chang,ZHAI Guang-xi. Preparation of dispersible nicotinylmethylmthylamidi tablets[J]. Journal of Shandong University:Health Sciences, 2003, 41(4): 451-452 | |
| Authors: | YONG De-qing ZANG Heng-chang ZHAI Guang-xi |
| Affiliation: | Qilu Hospital of Shandong University |
| Abstract: | Objective:To study the preparation of dispersible nicotinylmethylamidi tablets.Meth ods:With the dispersible time as the focus of attention,different disintegrants were compared and orthogonal design was adopted to determine the optimal formulation,and then dissolution rate of dispersible nicotinyl-methylamidi tablets was compared with that of the conventional tablets in the market.Results:Among the three tested disintegrants L-HPC had the shortest dispersing time and the dispersible tablets of optimal for-mulation exhibited a disintegrating time of78.9s with a much quicker dissolution speed than that of the conventional tablets on sale.Conclusion:The experimented dispersible nicotinylmethylamidi tablets have a higher dissolution speed than those in the market. |
| Keywords: | Niacinamide Dosage forms Orthogonal design |
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