| 发育期补充DHA对大鼠海马突触可塑性的影响 |
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| 引用本文： | 曹秀菁,黄升海.发育期补充DHA对大鼠海马突触可塑性的影响[J].中国药理学通报,2005,21(8):985-988. |
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| 作者姓名： | 曹秀菁 黄升海 |
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| 作者单位： | 1. 安徽医科大学,儿少卫生与妇幼保健系,安徽,合肥,230032
2. 安徽医科大学,临床药理研究所,安徽,合肥,230032 |
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| 基金项目： | 安徽省教育厅青年教师基金 |
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| 摘 要： | 目的探讨鱼油DHA对海马突触可塑性的影响,为DHA对学习记忆的作用提供电生理依据。方法将大鼠分为灌胃鱼油组和对照组,每天分别灌以5×103ml·g-1体重的鱼油和生理盐水,90d后运用在位电生理实验方法,刺激大鼠海马穿通纤维—齿状回通路,在同一动物上记录海马DG区的LTP和LTD。结果与对照组相比,鱼油组明显增强了PS诱导的LTP,对EPSP诱导的LTP无影响;对PS和EPSP诱导的LTD均有明显的减弱作用。结论补充鱼油对海马突触可塑性有一定影响,这种影响可能是鱼油提高学习记忆能力的生理依据之一。
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| 关 键 词： | 二十二碳六烯酸 突触可塑性 海马 |
| 文章编号： | 1001-1978（2005）08-0985-04 |
| 收稿时间： | 2005-02-10 |
| 修稿时间： | 2005-04-12 |
The effects of supplemented with DHA on synaptic plasticity during development period in rats |
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| CAO Xiu-jing,HUANG Sheng-hai.The effects of supplemented with DHA on synaptic plasticity during development period in rats[J].Chinese Pharmacological Bulletin,2005,21(8):985-988. |
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| Authors: | CAO Xiu-jing HUANG Sheng-hai |
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| Abstract: | Aim To discover the change of synaptic plasticity by supplementing DHA during development period in rats. Method We divided Wistar rats into two groups: fish oil group and control group. The fish oil rats were supplemented with fish oil(5×10~3 ml·g-1 body weight) by gavage daily. The control rat was supplemented with NS of the same dose. 90 days later, each rat was hippocampus of anaesthetized and LTP and LTD were recorded at hippocampus of the same rat. Result Compared to the control group, DHA group presented an obvious increase in PS LTP, while no changes were found in EPSP LTP. On the other hand,DHA group demonstrated an obvious canceling effect on both EPSP and PS LTD. Conclusion There exist effects on synaptic plasticity after supplement with DHA. It may be one of the factors that DHA improves learning and memory. |
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| Keywords: | DHA synaptic plasticity hippocampus |
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