不同透析膜对维持性血液透析者预后的影响

目的] 探讨不同透析膜对维持性血液透析(MHD)患者预后的影响.方法] 本院诊治的MHD患者105例,根据使用透析膜的不同分为三组,每组35例.A组采用B-16H型空心纤维血液透析器透析,B组采用F15型空心纤维血液透析器透析,C组采用CA-HP-150型血液透析器治疗,采用抑郁自评量表(SDS)及焦虑自评量表(SAS)评分进行抑郁评分测定,比较三组C反应蛋白(CRP)、白细胞介素-6(IL-6)及糖基化终末产物(AGEs)水平和甲状旁腺激素(PTH)、磷(P)、钙(Ca)及血清白蛋白(ALb)和血红蛋白(Hb)水平.结果] 三组治疗前SAS、SDS评分相比较差异无显著性(P>0.05);C组治疗后SAS、SDS评分低于A、B组(P<0.05);C组治疗后CRP、IL-6、AGEs及PTH、P水平显著低于A、B组(P<0.05);C组治疗后Ca及ALb和Hb水平显著高于A、B组(P<0.05).结论] MHD患者采用CA-HP-150型血液透析器治疗效果理想,其能改善患者矿物质代谢紊乱,缓解患者抑郁症状,值得推广应用.

Influence of Different Dialysis Membrane on the Prognosis of Maintenance Hemodialysis Patients

Objective]To observe the effect of different dialysis membrane on the prognosis of patients with maintenance hemodialysis (MHD).Methods]One hundred and five patients with MHD were divided into three groups according to different dialysis membrane.There were 35 patients with maintenance hemodialysis in each group.Group A was dialyzed with B-16H hollow fiber hemodialyzer, group B was dialyzed with F15 hollow fiber hemodialyzer and group C was treated with CA-HP-150 hemodialyzer.Depression levels were evaluated by self-rating depression scale (SDS) and self-rating anxiety scale (SAS).Meanwhile blood C reaction protein (CRP), interleukin-6 (IL-6), advanced glycosylation end products (AGEs), the levels of three groups of parathyroid hormone (PTH), phosphorus (P), calcium (Ca), serum albumin (ALb), and hemoglobin level (Hb) were measured.Results]There were no significant differences in terms of SAS and SDS scores among three groups before treatment (P>0.05).After different dialysis, the SAS and SDS scores in group C were lower than those in group A and B (P<0.05).The levels of CRP, IL-6,AGEs,PTH, and P in group C were significantly lower than those in group A and B (P<0.05).The Ca,Alb, and Hb levels of group C were significantly higher than those of group A and B (P<0.05).Conclusion]CA-Hp-150 hemodialyzer is an ideal therapy for maintenance hemodialysis patients.It can improve the patients' mineral metabolism disorders and alleviate the depressive symptoms.It is worthy of popularization and application.