微波消融、TACE与全身化疗治疗结直肠癌肝转移的疗效

[目的]探讨微波消融、介入栓塞化疗(TACE)序贯方案与全身化疗治疗结直肠癌肝转移的临床疗效.[方法]根据不同治疗方案将80例结直肠癌肝转移患者分为观察组(全身化疗+微波消融+TACE序贯治疗)与对照组(全身化疗),比较两组近期疗效,预后及治疗前后细胞免疫功能变化.[结果]观察组近期客观有效率为66.67％(28/42),高于对照组的42.10％(16/38),且差异有显著性(P<0.05);观察组首次治疗后CD3+、CD4+阳性率、CD4+/CD8+比值均显著大于,CD8+显著小于同组治疗前、对照组治疗后(均P<0.05);观察组中位存活时间26.00个月长于对照组的13.60个月(P<0.05).[结论]在全身化疗基础上,行微波消融+TACE治疗能显著提高结直肠癌肝转移患者的有效率,明显改善机体免疫功能,延长患者存活时间.

Comparison of Prognosis of Patients with Liver Metastases of Colorectal Cancer Treated by Microwave Ablation,Transhepatic Arterial Chemotherapy and Embolization and Systemic Chemotherapy

[Objective]To compare the prognosis of patients with liver metastases of colorectal cancer treated by microwave ablation, transhepatic arterial chemotherapy and embolization (TACE) and systemic chemotherapy.[Methods]According to different treatment methods, 80 cases of patients with liver metastases of colorectal cancer were divided into the observation group (treated by microwave ablation+TACE sequential therapy) and the control group (treated by systemic chemotherapy).The short-term curative effect and prognosis (survival) were compared between the two groups, and the changes of cell immune function before and after treatment were determined and recorded.[Results]The short-term objective response rate (ORR) of the observation group was 66.67％ (28/42)while that of the control group was 42.10％(16/38), and the difference was significant (P<0.05).After initial treatment, positive rate of CD3+, CD4+ and the ratio CD4+/CD8+ were significantly higher, and CD8+ was significantly lower in the observation group than those in the same group before treatment and those in the control group after treatment (P<0.05).The median survival time of the observation group was 26.00 months while that of the control group was 13.60 months (P<0.05).[Conclusion]On the basis of systemic chemotherapy , microwave ablation + TACE can significantly improve the effective rate of treatment for patients with liver metastases of colorectal cancer, significantly improve the immune function and prolong the survival time of patients.