中孕期羊水中细胞因子水平与中年妇女自发性早产的相关性探讨

目的]探讨中孕期羊水中细胞因子水平与中年妇女自发性早产的相关性.方法]将本院2014年3至2015年11月收治的自发性早产的孕妇43例作为早产组,选取同期正常孕足月的孕妇40例作为正常组.抽取两组孕妇的羊水,检测细胞因子水平,分析其与中年妇女自发性早产的相关性.结果]早产组的白介素16(IL-16)、白介素8(IL-8)、白介素6(IL-6)、C反应蛋白(CRP)、肿瘤坏死因子α(TNF-α)分别为(201.37±18.74) pg/mL、(786.14±146.28)pg/mL、(141.25±13.87)pg/mL、(176.22±12.34) ng/mL、(114.27±15.64)pg/mL,均分别明显高于正常组(157.46±10.43) pg/mL、(413.91±84.67)pg/mL、(122.94±8.63) pg/mL、(132.18士8.64)ng/mL、(76.48±7.69)pg/mL,其差异均有统计学意义(P＜0.05).相关性分析显示,IL-16、IL-8、IL-6、CRP、TNF-α水平均与中年妇女发生自发性早产密切相关(P＜0.05).结论]中孕期羊水中细胞因子水平与中年妇女自发性早产的密切相关,可作为临床早期预测早产发生的一类指标.

Correlation between Cytokine Levels in Amniotic Fluid of Second Trimester with Spontaneous Preterm Delivery in Middle-aged Pregnant Women

Objective]To study the correlation between cytokine levels in amniotie fluid during the second trimester and spontaneous preterm delivery in middle-aged women.Methods]Forty-three pregnant women with spontaneous preterm delivery who were admitted to our hospital from March 2014 to November 2015 were selected as the premature group.Forty normal pregnant women were selected as the control group.The levels of cytokines (IL-16,IL-8,IL-6,CRP,and TNF-α) were measured from amniotic fluid of the two groups,and the correlation of cytokines' level with spontaneous preterm delivery was analyzed.Results]The levels of IL-16,IL-8,IL-6,CRP and TNF-α in premature group were (201.37±18.74)pg/mL、(786.14±146.28)pg/mL,(141.25±13.87)pg/mL,(176.22±12.34)ng/mL,and(114.27±15.64)pg/mL,respectively,significantly higher than those in the control group(157.46 ± 10.43) pg/mL,(413.91 ± 84.67) pg/mL,(122.94 ± 8.63) pg/mL,(132.18 ± 8.64) ng/mL,and (76.48±7.69)pg/mL],respectively.The differences were statistically significant (P ＜0.05).Through the logistic analysis of influencing factors,the levels of IL-16,IL-8,IL-6,CRP and TNF-α were found to be significantly correlated with the occurrence of spontaneous preterm birth in middle-aged women (P ＜0.05).Conclusion] The level of cytokines in amniotic fluid of middle pregnancy is closely related to the occurrence of spontaneous preterm delivery in middle-aged pregnant women,and it can be used as early clinical screening indicators.