E2F-1在胃癌癌组织中的表达及其与预后的关系

目的]探讨转录因子E2F-1在胃癌癌组织中的表达及其与预后的关系.方法]检测80例胃癌患者胃癌组织、癌旁正常组织中的E2E-1表达情况,对其临床病理特征及预后进行分析.结果]胃癌组织中E2F-1的阳性表达率为71.25%(57/80),高于癌旁正常组织23.75%(P<0.05);E2F-1阳性表达与阴性表达患者的性别、年龄、组织学类型、肿瘤位置、分化程度、TNM分期、淋巴结转移相比较差异均无显著性(P>0.05);E2F-1阳性表达患者2年生存率为47.37%(27/57),低于阴性表达的73.91%(17/23)(P<0.05);Cox模型单因素分析显示肿瘤位置、分化程度、TNM分期、淋巴结转移与胃癌患者总生存时间有关(P<0.05),多因素分析发现淋巴结转移、E2F-1阳性表达是影响胃癌患者生存时间的独立危险因素.结论]E2F-1是胃癌恶性行为的标志之一,是预后不良的重要影响因子.

Analysis of E2F-1 Expression in Gastric Cancer Tissues and Its Relationship with Prognosis

Objective] To investigate the expression of E2F-1 in gastric cancer tissues and its relationship with prognosis.Methods]Eighty patients with gastric cancer in our hospital were enrolled in the study.The expression of E2E-1 in gastric cancer tissues and adjacent normal tissues was detected, and the clinicopathological features and prognosis were analyzed.Results]The positive expression rate of E2F-1 in gastric cancer tissues (71.25%) was significantly higher than that in adjacent normal tissues (23.75%) (P<0.05).There were no significant differences in positive and negative expressions of E2F-1 in relation to gender, age, histological type, tumor location, differentiation, TNM stage and lymph node metastasis in patients (P>0.05).The 2-year survival rate of patients with positive expression of E2F-1 (47.37%) was lower than that of patients with negative expression (73.91%), and the difference was statistical significant (P<0.05).Cox model univariate analysis showed that tumor location, differentiation degree, TNM stage and lymph node metastasis were related to the overall survival time of patients with gastric cancer (P<0.05).Multivariate analysis showed that lymph node metastasis and positive expression of E2F-1 were the independent risk factors influencing the survival time of patients with gastric cancer.Conclusion] E2F-1 is one of the signs of malignant behavior for gastric cancer and is an important influencing factor for poor prognosis.