幽门螺杆菌感染与胃癌肝转移的相关性分析

[目的]探讨幽门螺杆菌(Hp)感染与胃癌肝转移的相关性.[方法]120例胃癌患者按照是否存在肝转移分为肝转移组(n=52)和非肝转移组(n=68),对两组患者临床资料中危险因素进行单因素分析,将与胃癌肝转移有关的因素进行Logistic多因素回归分析,根据14C尿素呼气试验结果将胃癌肝转移患者分为Hp阳性组和Hp阴性组,比较两组患者生存曲线关系.[结果]两组患者在肿瘤分期、淋巴结转移、原发灶浸润深度、脉管浸润、肿瘤大小、Borrmann分型及Hp感染等方面比较差异均具有显著性(P<0.05).经Logistic多元回归分析显示,肿瘤分期、淋巴结转移、原发灶浸润深度、Hp感染是胃癌肝转移发生的独立危险因素.胃癌肝转移患者中Hp阴性组平均生存时间显著长于Hp阳性组(P<0.05).[结论]淋巴结转移、脉管浸润和Hp感染是胃癌肝转移发生的独立危险因素,且Hp感染能够影响胃癌肝转移无进展生存期时间.

Correlation between Helicobacter Pylori Infection and Liver Metastases of Gastric Cancer

[Objective]To investigate the correlation between Helicobacter pylori (Hp) infection and liver metastases of gastric cancer.[Methods]A total of 120 patients with gastric cancer were divided according to the presence of metastases into the liver metastasis group (n=52) and the non-liver metastasis group (n=68).The risk factors of clinical data from the two groups were analyzed by univariate analysis.Factors related to liver metastases of gastric cancer were analyzed by Logistic regression analysis.Based on the results of 14C urea breath test, the patients with liver metastases of gastric cancer were further divided into Hp positive sub-group and Hp negative sub-group, and the survival curves were compared between the two sub-groups.[Results]There were significant differences between the liver metastasis and non-liver metastasis groups in terms of tumor stage, lymph node metastasis, depth of primary tumor invasion, vascular invasion, tumor size, Borrmann type and Hp infection (P<0.05).Logistic multivariate regression analysis showed that tumor stage, lymph node metastasis, depth of primary tumor invasion and Hp infection were independent risk factors for liver metastases of gastric cancer.The mean survival time of Hp negative group was significantly longer than that of Hp positive group (P<0.05).[Conclusion]Lymph node metastasis, vascular invasion and Hp infection are the independent risk factors of liver metastases of gastric cancer, and Hp infection can affect the progression-free survival time of patients with liver metastases of gastric cancer.