Nm23、IMP3蛋白在乳腺浸润性导管癌组织中的表达及其临床意义

目的 研究nm23、IMP3蛋白在乳腺浸润性导管癌组织中的表达及两者之间的关系,并探讨其临床意义.方法 采用免疫组化S-P法检测nm23和IMP3在乳腺浸润性导管癌组织和癌旁组织中的表达情况,分析两者的相关性,再对nm23、 IMP3蛋白在乳腺浸润性导管癌及癌旁组织中的表达与淋巴结转移之间的关系进行统计学分析.结果 乳腺浸润性导管癌组织中nm23的表达低于癌旁组织(P<0.05);乳腺浸润性导管癌组织中IMP3的表达高于癌旁组织(P<0.05).淋巴结转移者nm23的表达低于无淋巴结转移者(P<0.05);淋巴结转移者IMP3蛋白的表达高于无淋巴结转移者(P<0.05).乳腺浸润性导管癌组织中nm23与IMP3蛋白的表达呈负相关(r=-0.795,P<0.5).结论 Nm23、IMP3蛋白表达在乳腺浸润性导管癌的形成和转移中起着重要作用,可作为预测其浸润转移潜能的重要指标.

Expressions and Clinical Significance of Nm23 and IMP3 in the Breast Invasive Duct Carcinoma

Objective To explore the expressions and their clinical significance of nm23 and IMP3 in the breast invasive duct carcinoma.Methods The expressions of nm23 and IMP3 were detected by immunohistochemistry S-P method in the breast invasive duct carcinoma tissues and the corresponding adjacent normal tissues.The correlation between nm23 and IMP3 was analyzed.A statistical analysis was done between the expression of them and lymph node metastasis status.Results The positive expression rate of nm23 in the breast invasive duct carcinoma tissues was significantly lower than that in the corresponding adjacent normal tissues (P<0.05);the positive expression rate of IMP3 in the breast invasive duct carcinoma tissues was higher than that in corresponding adjacent normal tissues (P<0.05).The expression level of nm23 in the breast invasive duct carcinoma tissues with lymphatic metastasis was lower than that of the ones without lymphatic metastasis (P<0.05);but the expression level of IMP3 in the breast invasive duct carcinoma tissues was higher than that of the ones without lymphatic metastasis (P<0.05).Nm23 and IMP3 protein expression were negatively correlated in the breast invasive duct carcinoma(r=-0.795,P<0.05).Conclusion Nm23 and IMP3 play an important role in the carcinogensis and metastasis of breast invasive duct carcinoma,may be used as an indicator of invasive and metastasis potential.