| Ⅲ-Ⅳ期声门区喉癌超分割放疗的临床疗效分析 |
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| 引用本文： | 林连兴,徐志渊,蔡舜吼,张庆宏. Ⅲ-Ⅳ期声门区喉癌超分割放疗的临床疗效分析[J]. 中国现代药物应用, 2009, 3(4) |
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| 作者姓名： | 林连兴 徐志渊 蔡舜吼 张庆宏 |
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| 作者单位： | 汕头市中心医院/中山大学附属汕头医院,515031 |
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| 摘 要： | 目的探讨超分割放疗治疗Ⅲ-Ⅳ期声门区喉癌的疗效和并发症情况。方法1999年1月至2003年8月来本院首诊的105例Ⅲ-Ⅳ期声门区喉癌患者,采用超分割放疗治疗,部分病例加用CF或PF方案化疗,放疗采用60Co-γ线外照射,1.2Gy/次,2次/d,5d/周,间隔≥6h,全疗程喉部原发灶剂量68～78Gy,颈部淋巴结转移灶放疗剂量68～80Gy。结果放化疗结束时完全缓解率为60.5%,1年生存率为74.3%,2年生存率57.1%,5年生存率为39%。皮肤反应≥2级的病例占29.5%,咽喉反应≥3级的病例占4.8%,结论超分割放疗患者能耐受,可以保留喉功能,疗效好,为晚期患者提供了一种有效的治疗方法,其确切疗效有待大规模临床试验验证。
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| 关 键 词： | 喉肿瘤/放射疗法 辐射损伤 预后 |
Clinical Outcome of treating patients with stage Ⅲ-Ⅳ glottic laryngeal cancer by hyperfractionated radiotherapy |
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| Affiliation: | LIN Lian-xing; XU Zhi-yuan; CAI Shun-hou; et al.The Affiliated Shantou Hospital of Sun Yat-sen University; Shantou; Guangdong 515031; China; |
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| Abstract: | Objective To approach the therapeutic effects and complication of hyperfractionated radiotherapy for stage Ⅲ-Ⅳ glottic laryngeal cancer.Methods Form January 1999 to August 2003,105 patients with stage Ⅲ-Ⅳ glottic laryngeal cancer were treated by hyperfractionated radiotherapy.For hyperfractionated radiotherapy,γ-ray from 60 Co were performed and two daily fractions of 1.2 Gy were given,with an interval of ≥6 hours,5 days per week to a dose range of 68-78 Gy for Laryngeal and 68-80 Gy for neck.For some patie... |
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| Keywords: | Laryngeal neoplasm /radiotherapy Radiation injuries Prognosis |
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