| 盐酸左旋沙丁胺醇口腔速崩片的研制 |
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| 引用本文： | 胡淑娟,范玉玲,季宇彬.盐酸左旋沙丁胺醇口腔速崩片的研制[J].上海医药,2007,28(7):301-303. |
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| 作者姓名： | 胡淑娟 范玉玲 季宇彬 |
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| 作者单位： | 哈尔滨商业大学生命科学与环境科学研究中心,哈尔滨,150076 |
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| 基金项目： | 黑龙江省哈尔滨市科技攻关项目 |
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| 摘 要： | 目的:研制盐酸左旋沙丁胺醇口腔速崩片。方法:采用正交设计法对盐酸左旋沙丁胺醇口腔速崩片处方进行筛选。结果:确定最佳处方为:微晶纤维素和低取代羟丙甲纤维素最佳配比为4:1的混合物用量为40%,交联聚乙烯吡咯烷酮用量10%,阿斯巴甜用量4%,柠檬酸用量6%。结论:盐酸左旋沙丁胺醇口腔速崩片能快速崩解,且释放迅速,口感舒适。
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| 关 键 词： | 盐酸左旋沙丁胺醇 口腔速崩片 崩解时间 正交设计 |
| 文章编号： | 1006-1533（2007）07-0301-03 |
| 修稿时间： | 2007-05-09 |
Preparation of levalbuterol hydrochloride orally disintegrating tablets |
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| Hu Shujuan,Fan Yuling,Ji Yubin.Preparation of levalbuterol hydrochloride orally disintegrating tablets[J].Shanghai Medical & Pharmaceutical Journal,2007,28(7):301-303. |
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| Authors: | Hu Shujuan Fan Yuling Ji Yubin |
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| Institution: | Life Science and Environmental Science Research Center, Harbin University of Commerce, Harbin, 150076 |
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| Abstract: | Objective:To prepare orally disintegrating tablets of levalbuterol hydrochloride.Methods:The orthogonal design was used to optimize the formulation of orally disintegrating tablets of levalbuterol hydrochloride.Results:The major ingredients in the optimized formulation of the tablets included 40% the mixture of microcrystalline cellulose and low-substituted hydroxypropylcellulose(4:1),10% polyvinylpolypyrrolidone,4% aspartame,and 6% citric acid.Conclusion:The prepared orally disintegrating tablets are quick to disintegrate and release and have desirable taste. |
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| Keywords: | levalbuterol hydrochloride orally disintegrating tablets disintegration time orthogonal design |
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