| 抢先治疗减少异基因造血干细胞移植后早期巨细胞病毒疾病的临床研究 |
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| 引用本文： | 卢岳,吴彤,曹星玉,王静波,孙媛,赵艳丽,达万明,纪树荃,童春容,张隆基,陆道培.抢先治疗减少异基因造血干细胞移植后早期巨细胞病毒疾病的临床研究[J].临床血液学杂志,2011(6):655-658,661. |
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| 作者姓名： | 卢岳 吴彤 曹星玉 王静波 孙媛 赵艳丽 达万明 纪树荃 童春容 张隆基 陆道培 |
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| 作者单位： | 北京市道培医院移植科;北京市道培医院临床特检中心;美国佛罗伦达大学细胞遗传与微生物实验室; |
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| 摘 要： | 目的:采用联合抗病毒药物及巨细胞病毒(CMV)特异性T淋巴细胞(CMV-CTL)进行抢先抗病毒治疗,减少异基因造血干细胞移植后早期CMV疾病的发生率和病死率.方法:334例进行异基因造血干细胞移植的患者,其中同胞相合移植100例,非血缘移植88例,亲缘间半相同移植146例；移植后采用RQ-PCR方法每周检测1～2次检测...
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| 关 键 词： | 异基因造血干细胞移植 巨细胞病毒 抢先治疗 |
Significant reduction of morbidity and mortality of early CMV disease after allogeneic hematopoietic cell transplantation by pre-emptive therapy with anti-viral drugs and CMV cytotoxic T lymphocytes |
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| LU Yue,WU Tong,CAO Xingyu,WANG Jingbo SUN Yuan,ZHAO Yanli DA Wanming,JI Shuquan,TONG Chunrong,ZHANG Longji,LU Daopei.Significant reduction of morbidity and mortality of early CMV disease after allogeneic hematopoietic cell transplantation by pre-emptive therapy with anti-viral drugs and CMV cytotoxic T lymphocytes[J].Journal of Clinical Hematology,2011(6):655-658,661. |
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| Authors: | LU Yue WU Tong CAO Xingyu WANG Jingbo SUN Yuan ZHAO Yanli DA Wanming JI Shuquan TONG Chunrong ZHANG Longji LU Daopei |
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| Institution: | LU Yue 1 WU Tong 1 CAO Xingyu 1 WANG Jingbo1 SUN Yuan 1 ZHAO Yanli1 DA Wanming 1 JI Shuquan 1 TONG Chunrong 2 ZHANG Longji 3 LU Daopei1 (1Department of Bone Marrow Transplantation,Beijing Daopei Hospital,Beijing,100049,China,2Department of Immunotherapy,3Molecular Genetics and Microbiology,University of Florida,Gainesville,USA) |
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| Abstract: | Objective:In present clinical study,morbidity and mortality of CMV disease after pre-emptive therapy with anti-viral drugs and CMV specific cytotoxic T lymphocytes(CMV-CTLs)in allo-HCT recipients were investigated.Method:From January 2007 to January 2009,334 patients who received allo-HCT were studied(matched sibling 100,unrelated 88,haploidentical 146).Plasma CMV DNA was monitored 1 to 2 times weekly with real time quantitative polymerase chain reaction(RQ-PCR).Ganciclovir was used for 8 days during condit... |
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| Keywords: | cytomegalovirus allogeneic hematopoietic cell transplantation therapy |
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