| 沙利度胺维持治疗对小细胞肺癌患者生存质量的影响 |
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| 引用本文： | 刘非,赵恩锋,孟祥玲,王国华,史福敏.沙利度胺维持治疗对小细胞肺癌患者生存质量的影响[J].临床误诊误治,2011,24(10):7-9. |
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| 作者姓名： | 刘非 赵恩锋 孟祥玲 王国华 史福敏 |
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| 作者单位： | 沧州中西医结合医院肿瘤内科,河北沧州,061000 |
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| 摘 要： | 目的应用沙利度胺进行小细胞肺癌(SCLC)维持治疗,观察其对患者生存质量的影响。方法将完成规定周期化疗28例SCLC随机分为治疗组和对照组,每组各14例。治疗组应用沙利度胺100 mg/d,连续睡前顿服至少2个疗程(21 d为1个疗程);对照组定期复查随访。结果治疗组和对照组的功能状态Karnofsky评分改善率分别为71.43%和28.57%,两组比较差异无统计学意义(P=0.075);体重增加率为64.29%和28.57%,两组比较差异无统计学意义(P=0.058);两组治疗前后、治疗组治疗前后、对照组治疗前后生活质量(QOL)评分比较,差异均无统计学意义(P>0.05)。治疗组6例出现轻度不良反应,两组均未见严重药物不良反应。结论沙利度胺用于SCLC的维持治疗是安全的,对患者的生存质量无明显影响。
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| 关 键 词： | 肺肿瘤 抗肿瘤药 治疗 生活质量 药物评价 |
Effects of Thalidomide on Life Quality in Patients with Small-cell Lung Cancer(SCLC) |
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| LIU Fei,ZHAO En-feng,MENG Xiang-ling,WANG Guo-hua,SHI Fu-min.Effects of Thalidomide on Life Quality in Patients with Small-cell Lung Cancer(SCLC)[J].Clinical Misdiagnosis & Mistherapy,2011,24(10):7-9. |
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| Authors: | LIU Fei ZHAO En-feng MENG Xiang-ling WANG Guo-hua SHI Fu-min |
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| Institution: | LIU Fei,ZHAO En-feng,MENG Xiang-ling,WANG Guo-hua,SHI Fu-min(Department of Oncology,Cangzhou Cooperation of Chinese and Western Medicine Hospital,Cangzhou,Hebei 061001,China) |
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| Abstract: | Objective To observe the effects of Thalidomide on the life quality of the SCLC patients as a maintenance treatment.Methods A total of 28 SCLC patients undergoing complete circular chemotherapy were randomly divided into treatment group and control group(n=14 in each).The treatment group was treated with Thalidomide(100 mg/d,in one single dose) before sleep for 2 courses of treatment(21 days as a course);the control group did not receive any intervention.Regular observations and follow-up were performed in ... |
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| Keywords: | Lung neoplasm Thalidomide Maintenance therapy Quality of life Drug evaluation |
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