小剂量阿托伐他汀钙对颈动脉斑块患者血清P-选择素及血脂影响

目的观察小剂量阿托伐他汀钙对颈动脉斑块患者血清P-选择素及血脂的长期影响。方法选取有颈动脉斑的79例作为斑块组,随机分为斑块治疗组43例及斑块对照组36例;另选无颈动脉斑块30例作为无斑块组。斑块治疗组予阿托伐他汀钙、肠溶阿司匹林口服;斑块对照组仅予肠溶阿司匹林口服。观察治疗前和治疗后6个月、18个月P-选择素及血脂水平的变化,并记录两组终点事件及不良反应情况。无斑块组不予干预,仅留血用于P-选择素及血脂的对照研究。结果斑块治疗组和斑块对照组终点事件发生率差异无统计学意义(P>0.05)。无斑块组P-选择素水平明显低于斑块组,差异有统计学意义(P<0.05)。治疗组6个月和18个月P-选择素水平与治疗前比较明显降低,差异有统计学意义(P<0.05)。对照组P-选择素水平在18个月观察期内差异均无统计学意义(P>0.05)。治疗组6、18个月时血胆固醇、低密度脂蛋白水平明显降低,与治疗前比较差异有统计学意义(P<0.01),18个月甘油三酯水平降低,高密度脂蛋白升高,与治疗前比较差异有统计学意义(P<0.05)。对照组血脂各项指标在18个月观察期内差异均无统计学意义(P>0.05)。治疗组与对照组不同时间点血脂水平比较差异均有统计学意义(P<0.05,P<0.01)。治疗组无严重不良反应。结论小剂量阿托伐他汀钙在调脂的同时,还可通过抑制炎症介质P-选择素抑制炎性反应,稳定斑块,从而预防缺血性脑血管病的发生。

The Effects of Low-dose Atorvastatin Calcium on P-selectin and Blood Lipid in Patients with Carotid Artery Plaque

Objective To observe the long-term effect of low-dose Atorvastatin calcium on P-selectin and lipids levels in blood serum of the patients with carotid artery plaque.Methods 79 patients with carotid artery plaque were randomly divided into treatment group(n=43) and control group(n=36),and 30 controls without carotid artery plaque were enrolled as non-plaque group.The treatment group received oral Atorvastatin calcium and enteric coated aspirin.The control group only received enteric coated aspirin treatment....