| 超声评价骨髓间充质干细胞在外周神经缺损修复中的价值 |
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| 引用本文： | 曹敏丽,赵红斌,吕志成.超声评价骨髓间充质干细胞在外周神经缺损修复中的价值[J].临床误诊误治,2011,24(12):4-5. |
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| 作者姓名： | 曹敏丽 赵红斌 吕志成 |
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| 作者单位： | 兰州军区兰州总医院超声诊断科,兰州,730050 |
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| 基金项目： | 兰州军区医药卫生科研项目(LXH-2007007) |
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| 摘 要： | 目的通过超声评价骨髓间充质干细胞(mesenchyal stem cells,MSCs)在外周神经缺损修复中的价值。方法利用壳聚糖包被中药单体川芎嗪制备的缓释微球和胶原蛋白混合构建组织诱导性神经导管,应用大鼠MSCs予体外诱导,选择Wistar大鼠8只,随机分为MSCs组和无MSCs组,分别在连接后7 d、30 d和90 d时应用超声跟踪观察缺损神经的生长修复情况。结果 MSCs组神经导管内的缺损神经生长早于无MSCs组,MSCs组神经导管内的缺损神经纤维数量多于无MSCs组,MSCs组神经导管降解快于无MSCs组。结论 MSCs能显著促进缺损神经的修复。而超声对于评价MSCs在周围神经缺损修复中的作用具有重要价值。
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| 关 键 词： | 间质干细胞 外周神经 修复 超声检查 |
The Evaluation of Mesenchymal Stem Cells in Repairing the Defects of Reripheral Nerve by Ultrasound |
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| CAO Min-li,ZHAO Hong-bin,LV Zhi-cheng.The Evaluation of Mesenchymal Stem Cells in Repairing the Defects of Reripheral Nerve by Ultrasound[J].Clinical Misdiagnosis & Mistherapy,2011,24(12):4-5. |
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| Authors: | CAO Min-li ZHAO Hong-bin LV Zhi-cheng |
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| Institution: | CAO Min-li,ZHAO Hong-bin,LV Zhi-cheng(Department of Ultrasound,Lanzhou General Hospital of Lanzhou Military Area Command,Lanzhou 730050,China) |
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| Abstract: | Objective To evaluate the role of mesenchymal stem cells(MSCs) in repairing the peripheral nerve defects by ultrasound.Methods The organization of induced nerve conduit was builded by tetramethylpyrazine coated slow-release microspheres using chitosan and collagen,and then were induced by the rat bone marrow MSCs in vitro.8 Wistar rats were selected and randomly divided into MSCs group and non-MSCs group.The situations of growth and repair in nerve defects were observed by ultrasound,7 d,30 d and 90 d,respe... |
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| Keywords: | Mesenchymal stem cell Peripheral nerve Repair Ultrasonography |
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